Changes in macrophages in spleen and lymph nodes during acute African swine fever: expression of cytokines.
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Salguero, FJ, Ruiz-Villamor, E, Bautista, MJ, Sánchez-Cordón, PJ, Carrasco, L and Gómez-Villamandos, JC (2002) Changes in macrophages in spleen and lymph nodes during acute African swine fever: expression of cytokines. Vet Immunol Immunopathol, 90 (1-2). pp. 11-22.
Full text not available from this repository.Abstract
To gain further insight into the pathogenesis of African swine fever (ASF), the cytokine expression by macrophages in spleen and lymph nodes were examined. Twenty-one piglets were inoculated with the highly virulent isolate Spain-70 of ASF virus and killed in groups at 1-7 post-inoculation days (pid). An increase in the immunohistochemical detection of proinflammatory monokines in spleen and renal and gastrohepatic lymph nodes is reported, along with an increase in the serum levels of TNF-alpha and IL-1 beta. The expression of these cytokines is detected simultaneously in time and space with the viral protein 73 (vp 73) of the ASF virus detection. Our results demonstrate that mononuclear phagocyte system cell activation results in the release of several cytokines that could induce apoptosis of lymphocytes and haemodynamic changes.
| Item Type: | Article | |||||||||||||||||||||
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| Date : | November 2002 | |||||||||||||||||||||
| Uncontrolled Keywords : | African Swine Fever, African Swine Fever Virus, Animals, Female, Immunohistochemistry, Interleukins, Lymph Nodes, Macrophage Activation, Macrophages, Male, Monokines, Spleen, Swine, Time Factors, Tumor Necrosis Factor-alpha | |||||||||||||||||||||
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| Depositing User : | Symplectic Elements | |||||||||||||||||||||
| Date Deposited : | 17 May 2017 10:08 | |||||||||||||||||||||
| Last Modified : | 17 May 2017 10:08 | |||||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/826574 |
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