Evolution of T lymphocytes and cytokine expression in classical swine fever (CSF) virus infection.

Sánchez-Cordón, PJ, Núñez, A, Salguero, FJ, Carrasco, L and Gómez-Villamandos, JC (2005) Evolution of T lymphocytes and cytokine expression in classical swine fever (CSF) virus infection. J Comp Pathol, 132 (4). pp. 249-260.

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Abstract

This study characterized the cell-mediated immune response in pigs inoculated with the Alfort 187 isolate of classical swine fever (CSF) virus. Quantitative changes in the T-lymphocyte population (CD3(+), CD4(+) and CD8(+)) and qualitative changes in cytokine expression (IL-2, IL-4 and IFNgamma) by these cells in serum, thymus and spleen were demonstrated. These changes coincided spatially and temporally with previously described quantitative and qualitative changes in monocyte-macrophage populations, thus demonstrating the contribution of the two cell populations to lymphoid depletion. Moreover, examination of cytokine expression in thymus and spleen samples revealed a type 1 cell-mediated immune response in the early and middle stages of the experiment, giving way to a type 2 immune response towards the end of the experiment; these findings, which accorded with the serological results and lymphopenia, may influence the delayed humoral response characteristic of CSF.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Sánchez-Cordón, PJ, Núñez, A, Salguero, FJ, Carrasco, L and Gómez-Villamandos, JC
Date :	May 2005
DOI :	10.1016/j.jcpa.2004.10.002
Uncontrolled Keywords :	Animals, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Count, Classical Swine Fever, Classical swine fever virus, Cytokines, Female, Immunoenzyme Techniques, Interferon-gamma, Interleukin-2, Interleukin-4, Male, Spleen, Swine, Thymus Gland
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:08
Last Modified :	24 Jan 2020 18:33
URI:	http://epubs.surrey.ac.uk/id/eprint/826561

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