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Proinflammatory cytokines induce lymphocyte apoptosis in acute African swine fever infection.

Salguero, FJ, Sánchez-Cordón, PJ, Núñez, A, Fernández de Marco, M and Gómez-Villamandos, JC (2005) Proinflammatory cytokines induce lymphocyte apoptosis in acute African swine fever infection. J Comp Pathol, 132 (4). pp. 289-302.

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Twenty-one pigs inoculated with a highly virulent isolate (E70) of African swine fever (ASF) virus were killed 1-7 days later; a further three animals served as uninfected controls. An early increase in TNF-alpha, IL-1alpha, IL-1beta and IL-6 expression was detected in lymphoid organs from infected animals, together with an increase in the serum concentrations of TNF-alpha and IL-1beta. These changes were accompanied by increased apoptosis of lymphocytes, and the presence of infected and uninfected macrophages showing changes indicative of secretory and phagocytic activation. The present study demonstrated an increase in the number of macrophages expressing TNF-alpha, IL-1 and IL-6 in proximity to lymphocytes undergoing apoptosis, supporting previous suggestions that in acute ASF proinflammatory cytokines induce lymphocyte apoptosis.

Item Type: Article
Authors :
Salguero, FJ
Sánchez-Cordón, PJ
Núñez, A
Fernández de Marco, M
Gómez-Villamandos, JC
Date : May 2005
Identification Number : 10.1016/j.jcpa.2004.11.004
Uncontrolled Keywords : African Swine Fever, Animals, Apoptosis, Asfarviridae, Cell Count, Cytokines, Female, In Situ Nick-End Labeling, Lymph Nodes, Lymphocytes, Lymphoid Tissue, Macrophage Activation, Macrophages, Male, Spleen, Swine, Thymus Gland
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:08
Last Modified : 17 May 2017 10:08

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