Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model.

Castilla, J, Brun, A, Díaz-San Segundo, F, Salguero, FJ, Gutiérrez-Adán, A, Pintado, B, Ramírez, MA, del Riego, L and Torres, JM (2005) Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model. J Virol, 79 (13). pp. 8665-8668.

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Abstract

In this work we show evidence of mother-to-offspring transmission in a transgenic mouse line expressing bovine PrP (boTg) experimentally infected by intracerebral administration of bovine spongiform encephalopathy (BSE) prions. PrP(res) was detected in brains of newborns from infected mothers only when mating was allowed near to the clinical stage of disease, when brain PrP(res) deposition could be detected by Western blot analysis. Attempts to detect infectivity in milk after intracerebral inoculation in boTg mice were unsuccessful, suggesting the involvement of other tissues as carriers of prion dissemination. The results shown here prove the ability of BSE prions to spread centrifugally from the central nervous system to peripheral tissues and to offspring in a mouse model. Also, these results may complement previous epidemiological data supporting the occurrence of vertical BSE transmission in cattle.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Castilla, J, Brun, A, Díaz-San Segundo, F, Salguero, FJ, Gutiérrez-Adán, A, Pintado, B, Ramírez, MA, del Riego, L and Torres, JM
Date :	July 2005
DOI :	10.1128/JVI.79.13.8665-8668.2005
Uncontrolled Keywords :	Animals, Brain Chemistry, Cattle, Encephalopathy, Bovine Spongiform, Infectious Disease Transmission, Vertical, Injections, Mice, Mice, Transgenic, Models, Genetic, Prions
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:08
Last Modified :	24 Jan 2020 18:33
URI:	http://epubs.surrey.ac.uk/id/eprint/826558

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