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Acute phase response in porcine reproductive and respiratory syndrome virus infection.

Gómez-Laguna, J, Salguero, FJ, Pallarés, FJ, Fernández de Marco, M, Barranco, I, Cerón, JJ, Martínez-Subiela, S, Van Reeth, K and Carrasco, L (2010) Acute phase response in porcine reproductive and respiratory syndrome virus infection. Comp Immunol Microbiol Infect Dis, 33 (6). e51-e58.

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This study was focused on the changes observed in the serum concentration of haptoglobin (Hp), C-reactive protein (CRP), serum amyloid A (SAA) and Pig-major acute protein (Pig-MAP), during experimental porcine reproductive and respiratory syndrome virus (PRRSV) infection and in their relationship with the expression of interleukin 1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). Hp and Pig-MAP serum levels were increased at 10 dpi, but CRP and SAA showed a delayed and highly variable increase. All three proinflammatory cytokines were poorly expressed, and only a mild increase in IL-1β was observed at 7 dpi. The increased expression of Hp coincided with the light enhancement observed in both IL-6 and TNF-α, and might be related with an increased expression of IL-10. The low expression of TNF-α might point to a possible mechanism of viral evasion of host-immune response. This issue and the delayed expression of CRP and SAA should be taken into account in future studies about modulation of the immune response by PRRSV infection.

Item Type: Article
Authors :
Gómez-Laguna, J
Salguero, FJ
Pallarés, FJ
Fernández de Marco, M
Barranco, I
Cerón, JJ
Martínez-Subiela, S
Van Reeth, K
Carrasco, L
Date : December 2010
DOI : 10.1016/j.cimid.2009.11.003
Uncontrolled Keywords : Acute-Phase Proteins, Acute-Phase Reaction, Animals, C-Reactive Protein, Cytokines, Enzyme-Linked Immunosorbent Assay, Haptoglobins, Immunomodulation, Interleukin-1beta, Interleukin-6, Porcine Reproductive and Respiratory Syndrome, Porcine respiratory and reproductive syndrome virus, Serum Amyloid A Protein, Swine, Tumor Necrosis Factor-alpha, Viremia
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:08
Last Modified : 17 May 2017 10:08

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