University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Challenges and responses in human vaccine development.

Kaufmann, SH, Juliana McElrath, M, Lewis, DJ and Del Giudice, G (2014) Challenges and responses in human vaccine development. Curr Opin Immunol, 28C. pp. 18-26.

Full text not available from this repository.

Abstract

Human vaccine development remains challenging because of the highly sophisticated evasion mechanisms of pathogens for which vaccines are not yet available. Recent years have witnessed both successes and failures of novel vaccine design and the strength of iterative approaches is increasingly appreciated. These combine discovery of novel antigens, adjuvants and vectors in the preclinical stage with computational analyses of clinical data to accelerate vaccine design. Reverse and structural vaccinology have revealed novel antigen candidates and molecular immunology has led to the formulation of promising adjuvants. Gene expression profiles and immune parameters in patients, vaccinees and healthy controls have formed the basis for biosignatures that will provide guidelines for future vaccine design.

Item Type: Article
Authors :
NameEmailORCID
Kaufmann, SHUNSPECIFIEDUNSPECIFIED
Juliana McElrath, MUNSPECIFIEDUNSPECIFIED
Lewis, DJd.j.lewis@surrey.ac.ukUNSPECIFIED
Del Giudice, GUNSPECIFIEDUNSPECIFIED
Date : 18 February 2014
Identification Number : https://doi.org/10.1016/j.coi.2014.01.009
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:07
Last Modified : 17 May 2017 14:47
URI: http://epubs.surrey.ac.uk/id/eprint/826484

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800