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Distribution of lesions in fetal brains following experimental infection of pregnant sheep with Toxoplasma gondii.

O'Donovan, J, Proctor, A, Gutierrez, J, Worrell, S, Nally, J, Marques, P, Brady, C, McElroy, M, Sammin, D, Buxton, D, Maley, S, Bassett, H and Markey, B (2012) Distribution of lesions in fetal brains following experimental infection of pregnant sheep with Toxoplasma gondii. Vet Pathol, 49 (3). pp. 462-469.

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Abstract

Six ovine fetal brains were harvested 33 to 35 days postchallenge from 5 ewes, each of which was given 3000 Toxoplasma gondii oocysts on day 90 of pregnancy. Histopathologic examination of transverse sections taken at 13 levels in the fetal brains revealed the presence of toxoplasmosis-related lesions in all 6 brains. However, lesions were not randomly distributed (P = .007); they were most numerous at the level of the optic tract, the rostral margin of the pons, and 4 mm caudal to the ansate sulcus and were absent in all sections at the level of the caudal cerebellum. Lesion distribution may be due to hemodynamic factors, differences in the expression of endothelial surface receptor molecules at the level of the blood-brain barrier, or the presence of localized permissive/inhibitory factors within the brain. The results have implications for the selection of areas of brain from aborted ovine fetuses to be examined histopathologically for laboratory diagnosis.

Item Type: Article
Authors :
NameEmailORCID
O'Donovan, JUNSPECIFIEDUNSPECIFIED
Proctor, AUNSPECIFIEDUNSPECIFIED
Gutierrez, Jj.gutierrez@surrey.ac.ukUNSPECIFIED
Worrell, SUNSPECIFIEDUNSPECIFIED
Nally, JUNSPECIFIEDUNSPECIFIED
Marques, PUNSPECIFIEDUNSPECIFIED
Brady, CUNSPECIFIEDUNSPECIFIED
McElroy, MUNSPECIFIEDUNSPECIFIED
Sammin, DUNSPECIFIEDUNSPECIFIED
Buxton, DUNSPECIFIEDUNSPECIFIED
Maley, SUNSPECIFIEDUNSPECIFIED
Bassett, HUNSPECIFIEDUNSPECIFIED
Markey, BUNSPECIFIEDUNSPECIFIED
Date : May 2012
Identification Number : https://doi.org/10.1177/0300985811424732
Uncontrolled Keywords : Animals, Brain, Enzyme-Linked Immunosorbent Assay, Female, Histological Techniques, Infectious Disease Transmission, Vertical, Pregnancy, Real-Time Polymerase Chain Reaction, Sheep, Sheep Diseases, Toxoplasmosis, Animal
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:00
Last Modified : 17 May 2017 14:46
URI: http://epubs.surrey.ac.uk/id/eprint/826020

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