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Interferon-γ expression in trophoblast cells in pregnant ewes challenged with Chlamydophila abortus.

Worrall, S, Sammin, DJ, Bassett, HF, Reid, CR, Gutierrez, J, Marques, PX, Nally, JE, O'Donovan, J, Williams, EJ, Proctor, A and Markey, BK (2011) Interferon-γ expression in trophoblast cells in pregnant ewes challenged with Chlamydophila abortus. J Reprod Immunol, 90 (2). pp. 214-219.

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Abstract

Pregnant ewes were challenged with Chlamydia abortus at 91-98 days of gestation and euthanised at 14, 21 and 28 days post-challenge. IFNγ mRNA labelling appeared to be co-localised with Chlamydial lipopolysaccharide within trophoblast cells in discrete areas lining the primary villi in the limbus and hilar zone of the placentomes from challenged sheep on days 21 and 28 post-infection. The presence of IFNγ was also demonstrated by immunohistochemistry. No labelling was seen in tissues from the non-infected ewes. The presence of IFNγ in trophoblast cells from infected ewes may indicate an attempt to restrict the replication of the organism and be an important trigger for the inflammatory responses that develop on the fetal side of the placenta in enzootic abortion.

Item Type: Article
Authors :
NameEmailORCID
Worrall, SUNSPECIFIEDUNSPECIFIED
Sammin, DJUNSPECIFIEDUNSPECIFIED
Bassett, HFUNSPECIFIEDUNSPECIFIED
Reid, CRUNSPECIFIEDUNSPECIFIED
Gutierrez, Jj.gutierrez@surrey.ac.ukUNSPECIFIED
Marques, PXUNSPECIFIEDUNSPECIFIED
Nally, JEUNSPECIFIEDUNSPECIFIED
O'Donovan, JUNSPECIFIEDUNSPECIFIED
Williams, EJUNSPECIFIEDUNSPECIFIED
Proctor, AUNSPECIFIEDUNSPECIFIED
Markey, BKUNSPECIFIEDUNSPECIFIED
Date : August 2011
Identification Number : https://doi.org/10.1016/j.jri.2011.03.011
Uncontrolled Keywords : Abortion, Septic, Animals, Chlamydophila, Chlamydophila Infections, Female, Interferon-gamma, Pregnancy, RNA, Messenger, Sheep, Sheep Diseases, Trophoblasts
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:00
Last Modified : 17 May 2017 14:46
URI: http://epubs.surrey.ac.uk/id/eprint/826000

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