An update on the pathogenesis of syringomyelia secondary to Chiari-like malformations in dogs.

Driver, CJ, Volk, HA, Rusbridge, C and Van Ham, LM (2013) An update on the pathogenesis of syringomyelia secondary to Chiari-like malformations in dogs. Vet J, 198 (3). pp. 551-559.

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Abstract

Syringomyelia (SM) is a spinal cord disease that can cause neuropathic pain in dogs. The pathogenesis of SM secondary to Chiari-like malformation (CM) has been the focus of intense research in recent years. The gulf in our understanding of CM/SM in dogs relative to the analogous human condition has progressively narrowed. CM is primarily a disease of abnormal geometric morphometry affecting the caudal cranial fossa and the brain parenchyma contained within it. This review describes how advanced imaging techniques have revealed a series of morphometric abnormalities associated with CM/SM. The series is presented in a logical order to help describe the pathogenesis of CM and the subsequent formation of syringes, with particular reference to the concepts of craniospinal compliance and cerebrospinal fluid pulse pressure timing.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :	Name Email ORCID Driver, CJ Volk, HA Rusbridge, C c.rusbridge@surrey.ac.uk Van Ham, LM
Date :	12 July 2013
DOI :	10.1016/j.tvjl.2013.07.014
Copyright Disclaimer :	Copyright © 2013 Elsevier Ltd. All rights reserved.
Uncontrolled Keywords :	Cavalier King Charles spaniels, Chiari-like malformation, Morphometrics, Neuropathic pain, Syringomyelia, Animals, Arnold-Chiari Malformation, Brain, Dog Diseases, Dogs, Skull, Spinal Cord, Syringomyelia
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 09:56
Last Modified :	16 Jan 2019 17:51
URI:	http://epubs.surrey.ac.uk/id/eprint/825711

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