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Mode of Virus Rescue Determines the Acquisition of VHS Mutations in VP22 Negative Viruses of Herpes Simplex Virus Type 1.

Ebert, K, Depledge, DP, Breuer, J, Harman, L and Elliott, G (2013) Mode of Virus Rescue Determines the Acquisition of VHS Mutations in VP22 Negative Viruses of Herpes Simplex Virus Type 1. J Virol.

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Abstract

Herpes simplex virus 1 deleted for VP22 is proposed to require secondary mutation of VHS for viability. Here we show that a replication-competent Δ22 virus constructed by homologous recombination maintains a Wt VHS gene and has no other gross mutations. By contrast, Δ22 viruses recovered from a bacterial artificial chromosome contain multiple codon changes within a conserved region of VHS. Hence, the mode of virus rescue influences the acquisition of secondary mutations.

Item Type: Article
Authors :
NameEmailORCID
Ebert, KUNSPECIFIEDUNSPECIFIED
Depledge, DPUNSPECIFIEDUNSPECIFIED
Breuer, JUNSPECIFIEDUNSPECIFIED
Harman, LUNSPECIFIEDUNSPECIFIED
Elliott, Gg.elliott@surrey.ac.ukUNSPECIFIED
Date : 17 July 2013
Identification Number : 10.1128/JVI.01654-13
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:55
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825667

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