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Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men.

Killick, E, Morgan, R, Launchbury, F, Bancroft, E, Page, E, Castro, E, Kote-Jarai, Z, Aprikian, A, Blanco, I, Clowes, V , Domchek, S, Douglas, F, Eccles, D, Evans, DG, Harris, M, Kirk, J, Lam, J, Lindeman, G, Mitchell, G, Pachter, N, Selkirk, C, Tucker, K, Zgajnar, J, Eeles, R and Pandha, H (2013) Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men. Sci Rep, 3.

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Abstract

Controversy surrounds the use of PSA as a biomarker for prostate cancer detection, leaving an unmet need for a novel biomarker in this setting; urinary EN2 may identify individuals with clinically relevant prostate cancer. Male BRCA1 and BRCA2 mutation carriers are at increased risk of clinically significant prostate cancer and may benefit from screening. Urine samples from 413 BRCA1 and BRCA2 mutation carriers and controls were evaluated. Subjects underwent annual PSA screening with diagnostic biopsy triggered by PSA > 3.0 ng/ml; 21 men were diagnosed with prostate cancer. Urinary EN2 levels were measured by ELISA and had a sensitivity of 66.7% and specificity of 89.3% for cancer detection. There was no statistically significant difference in EN2 levels according to genetic status or Gleason score. Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals.

Item Type: Article
Authors :
NameEmailORCID
Killick, EUNSPECIFIEDUNSPECIFIED
Morgan, Rr.morgan@surrey.ac.ukUNSPECIFIED
Launchbury, FUNSPECIFIEDUNSPECIFIED
Bancroft, EUNSPECIFIEDUNSPECIFIED
Page, EUNSPECIFIEDUNSPECIFIED
Castro, EUNSPECIFIEDUNSPECIFIED
Kote-Jarai, ZUNSPECIFIEDUNSPECIFIED
Aprikian, AUNSPECIFIEDUNSPECIFIED
Blanco, IUNSPECIFIEDUNSPECIFIED
Clowes, VUNSPECIFIEDUNSPECIFIED
Domchek, SUNSPECIFIEDUNSPECIFIED
Douglas, FUNSPECIFIEDUNSPECIFIED
Eccles, DUNSPECIFIEDUNSPECIFIED
Evans, DGUNSPECIFIEDUNSPECIFIED
Harris, MUNSPECIFIEDUNSPECIFIED
Kirk, JUNSPECIFIEDUNSPECIFIED
Lam, JUNSPECIFIEDUNSPECIFIED
Lindeman, GUNSPECIFIEDUNSPECIFIED
Mitchell, GUNSPECIFIEDUNSPECIFIED
Pachter, NUNSPECIFIEDUNSPECIFIED
Selkirk, CUNSPECIFIEDUNSPECIFIED
Tucker, KUNSPECIFIEDUNSPECIFIED
Zgajnar, JUNSPECIFIEDUNSPECIFIED
Eeles, RUNSPECIFIEDUNSPECIFIED
Pandha, Hh.pandha@surrey.ac.ukUNSPECIFIED
Date : 2013
Identification Number : 10.1038/srep02059
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:54
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825614

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