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Myokymia and neuromyotonia in 37 Jack Russell terriers.

Bhatti, SF, Vanhaesebrouck, AE, Van Soens, I, Martlé, VA, Polis, IE, Rusbridge, C and Van Ham, LM (2011) Myokymia and neuromyotonia in 37 Jack Russell terriers. Vet J, 189 (3). pp. 284-288.

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Abstract

The clinical and clinicopathological characteristics, treatment and outcome of vermicular muscle contractions (myokymia) and generalized muscle stiffness (neuromyotonia) in 37 Jack Russell terriers were evaluated retrospectively. Thirty dogs were affected by both disorders, whereas seven were presented with myokymia and never developed neuromyotonia. Clinical signs started at the mean age of 8 months. Except for signs of myokymia and neuromyotonia, clinical and neurological examination was normal in all dogs. Thirty dogs demonstrated typical signs of hereditary ataxia. Changes in serum chemistry included increased creatine kinase, aspartate aminotransferase and alanine aminotransferase concentrations. Electromyographic abnormalities, especially in muscles showing macroscopically visible myokymia, consisted of semirhythmic bursts of doublet, triplet, or multiplet discharges of a single motor unit. The amplitudes varied between 80 μV and 1 mV and occurred with an interburst frequency between 10 and 40 Hz and an intraburst frequency between 150 and 280 Hz. Most dogs were treated with a sodium channel blocker with variable results. Seven dogs died (most likely because of hyperthermia) or were euthanased during a neuromyotonic attack; 15 dogs were euthanased due to worsening of clinical signs, or lack of or no long-lasting effect of medication, and three were euthanased for unknown or unrelated reasons. Nine dogs were lost to follow-up and three were still alive 5-10.5 years after the start of clinical signs. In conclusion, young Jack Russell terriers with myokymia and neuromyotonia should undergo a complete blood and electrophysiological examination. Long-term prognosis is not favourable.

Item Type: Article
Authors :
NameEmailORCID
Bhatti, SFUNSPECIFIEDUNSPECIFIED
Vanhaesebrouck, AEUNSPECIFIEDUNSPECIFIED
Van Soens, IUNSPECIFIEDUNSPECIFIED
Martlé, VAUNSPECIFIEDUNSPECIFIED
Polis, IEUNSPECIFIEDUNSPECIFIED
Rusbridge, Cc.rusbridge@surrey.ac.ukUNSPECIFIED
Van Ham, LMUNSPECIFIEDUNSPECIFIED
Date : September 2011
Identification Number : 10.1016/j.tvjl.2010.07.011
Uncontrolled Keywords : Animals, Belgium, Blood Chemical Analysis, Dog Diseases, Dogs, Electromyography, Female, Follow-Up Studies, Isaacs Syndrome, Male, Myokymia, Retrospective Studies, Treatment Outcome
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:54
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825559

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