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Distribution of substance P and calcitonin gene-related peptide in the spinal cord of Cavalier King Charles Spaniels affected by symptomatic syringomyelia.

Hu, HZ, Rusbridge, C, Constantino-Casas, F and Jeffery, N (2012) Distribution of substance P and calcitonin gene-related peptide in the spinal cord of Cavalier King Charles Spaniels affected by symptomatic syringomyelia. Res Vet Sci, 93 (1). pp. 318-320.

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Abstract

The causes of clinical signs associated with syringomyelia in the Cavalier King Charles Spaniel (CKCS) are incompletely understood. In this study we compared expression of two pain-related neuropeptides: substance P (SP) and calcitonin gene related peptide (CGRP), in the spinal cord dorsal horn of normal dogs with that in CKCS with and without clinical signs of syringomyelia. There was a decrease in expression of both peptides in CKCS with 'symptomatic' syringomyelia that was also associated with significant asymmetry in SP-I and similar, though non-significant, asymmetry in CGRP-I compared with other groups. The asymmetric distribution of these pain-related peptides may be a consequence of syrinx-associated damage to grey matter but may also play a role in generation of pain.

Item Type: Article
Authors :
NameEmailORCID
Hu, HZUNSPECIFIEDUNSPECIFIED
Rusbridge, Cc.rusbridge@surrey.ac.ukUNSPECIFIED
Constantino-Casas, FUNSPECIFIEDUNSPECIFIED
Jeffery, NUNSPECIFIEDUNSPECIFIED
Date : August 2012
Identification Number : https://doi.org/10.1016/j.rvsc.2011.08.012
Uncontrolled Keywords : Animals, Calcitonin Gene-Related Peptide, Dog Diseases, Dogs, Spinal Cord, Substance P, Syringomyelia
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:53
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825552

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