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Effectiveness of breeding guidelines for reducing the prevalence of syringomyelia.

Knowler, SP, McFadyen, AK and Rusbridge, C (2011) Effectiveness of breeding guidelines for reducing the prevalence of syringomyelia. Vet Rec, 169 (26).

Full text not available from this repository.

Abstract

Several toy breed dogs are predisposed to syringomyelia (SM), a spinal cord disorder, characterised by fluid-filled cavitation. SM is a complex trait with a moderately high heritability. Selective breeding against SM is confounded by its complex inheritance, its late onset nature and high prevalence in some breeds. This study investigated the early outcome of existing SM breeding guidelines. Six hundred and forty-three dogs, 550 Cavalier King Charles spaniels (CKCS) and 93 Griffon Bruxellois (GB), were identified as having either one (454 dogs) or both parents (189 dogs) with MRI-determined SM status. Offspring without SM were more common when the parents were both clear of SM (SM-free; CKCS 70 per cent, GB 73 per cent). Conversely, offspring with SM were more likely when both parents had SM (SM-affected; CKCS 92 per cent, GB 100 per cent). A mating of one SM-free parent with an SM-affected parent was risky for SM affectedness with 77 per cent of CKCS and 46 per cent of GB offspring being SM-affected. It is recommended that all breeding dogs from breeds susceptible to SM be MRI screened; that the SM status at five years old is established; and all results submitted to a central database that can be used by dog breeders to better enable mate selection based on estimated breeding values.

Item Type: Article
Authors :
NameEmailORCID
Knowler, SPUNSPECIFIEDUNSPECIFIED
McFadyen, AKUNSPECIFIEDUNSPECIFIED
Rusbridge, Cc.rusbridge@surrey.ac.ukUNSPECIFIED
Date : 24 December 2011
Identification Number : https://doi.org/10.1136/vr.100062
Uncontrolled Keywords : Animals, Breeding, Dog Diseases, Dogs, Female, Genetic Predisposition to Disease, Genotype, Magnetic Resonance Imaging, Male, Pedigree, Selection, Genetic, Syringomyelia
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:53
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825551

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