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Long-term outcome of Cavalier King Charles spaniel dogs with clinical signs associated with Chiari-like malformation and syringomyelia.

Plessas, IN, Rusbridge, C, Driver, CJ, Chandler, KE, Craig, A, McGonnell, IM, Brodbelt, DC and Volk, HA (2012) Long-term outcome of Cavalier King Charles spaniel dogs with clinical signs associated with Chiari-like malformation and syringomyelia. Vet Rec, 171 (20).

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Abstract

The disease complex Chiari-like malformation (CM) and syringomyelia (SM) has been associated with the development of neuropathic pain (NeP), and commonly affects Cavalier King Charles spaniels (CKCS). This prospective cohort study followed 48 CKCSs with CM and/or SM and clinical signs suggestive of NeP for a period of 39 (±14.3) months from diagnosis. At the end of the study, 36 dogs were still alive; five dogs died of an unrelated or unknown cause, and seven were euthanased due to severe clinical signs suggestive of NeP. During the follow-up period, the clinical signs of scratching, facial rubbing behaviour, vocalisation and exercise ability were evaluated. Nine out of 48 dogs stopped scratching (P<0.001), but there was no statistically significant change in the number of dogs exhibiting exercise intolerance, vocalisation or facial rubbing behaviour. The overall severity of clinical signs based on a visual analogue scale (VAS) (0 mm: no clinical signs 100 mm: severe clinical signs) increased (from median 75 mm (interquartile ranges (IQR) 68-84) to 84 mm (IQR 71.5-91), P<0.001). A quarter of the dogs were static or improved. In general, the majority of the owners felt that the quality of life of their dogs was acceptable. Medical treatments received were gabapentin or pregabalin and/or intermittently, carprofen. The owner's perception of their animal's progress, and progress based on VAS, had strong positive correlation (Spearman's rank correlation (s(r)) 0.74, P<0.001). Overall, this study suggests that clinical signs suggestive of NeP progress in three-quarters of CKCSs with CM and/or SM.

Item Type: Article
Authors :
NameEmailORCID
Plessas, INUNSPECIFIEDUNSPECIFIED
Rusbridge, Cc.rusbridge@surrey.ac.ukUNSPECIFIED
Driver, CJUNSPECIFIEDUNSPECIFIED
Chandler, KEUNSPECIFIEDUNSPECIFIED
Craig, AUNSPECIFIEDUNSPECIFIED
McGonnell, IMUNSPECIFIEDUNSPECIFIED
Brodbelt, DCUNSPECIFIEDUNSPECIFIED
Volk, HAUNSPECIFIEDUNSPECIFIED
Date : 17 November 2012
Identification Number : https://doi.org/10.1136/vr.100449
Uncontrolled Keywords : Amines, Analgesics, Animals, Arnold-Chiari Malformation, Breeding, Carbazoles, Cohort Studies, Cyclohexanecarboxylic Acids, Dog Diseases, Dogs, Female, Male, Neuralgia, Pregabalin, Prospective Studies, Quality of Life, Severity of Illness Index, Syringomyelia, gamma-Aminobutyric Acid
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:53
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825549

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