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Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection.

Hingley-Wilson, SM, Casey, R, Connell, D, Bremang, S, Evans, JT, Hawkey, PM, Smith, GE, Jepson, A, Philip, S, Kon, OM and Lalvani, A (2013) Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection. Emerg Infect Dis, 19 (7). pp. 1138-1141.

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Abstract

Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.

Item Type: Article
Authors :
NameEmailORCID
Hingley-Wilson, SMUNSPECIFIEDUNSPECIFIED
Casey, Rrosalyn.casey@surrey.ac.ukUNSPECIFIED
Connell, DUNSPECIFIEDUNSPECIFIED
Bremang, SUNSPECIFIEDUNSPECIFIED
Evans, JTUNSPECIFIEDUNSPECIFIED
Hawkey, PMUNSPECIFIEDUNSPECIFIED
Smith, GEUNSPECIFIEDUNSPECIFIED
Jepson, AUNSPECIFIEDUNSPECIFIED
Philip, SUNSPECIFIEDUNSPECIFIED
Kon, OMUNSPECIFIEDUNSPECIFIED
Lalvani, AUNSPECIFIEDUNSPECIFIED
Date : July 2013
Identification Number : 10.3201/1907.130313
Uncontrolled Keywords : Mycobacterium tuberculosis, TB, antimicrobial resistance, bacteria, co-infection, drug sensitive, multidrug resistant, treatment resistance, tuberculosis and other mycobacteria, Aged, Antitubercular Agents, Coinfection, Culture Techniques, Delayed Diagnosis, Drug Resistance, Multiple, Bacterial, Drug Therapy, Combination, Ethambutol, Humans, Isoniazid, Male, Minisatellite Repeats, Molecular Diagnostic Techniques, Multilocus Sequence Typing, Mycobacterium tuberculosis, Treatment Outcome, Tuberculosis, Multidrug-Resistant, Tuberculosis, Pulmonary
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:53
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825544

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