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A new EEG biomarker of neurobehavioural impairment and sleepiness in sleep apnea patients and controls during extended wakefulness.

D'Rozario, AL, Kim, JW, Wong, KK, Bartlett, DJ, Marshall, NS, Dijk, DJ, Robinson, PA and Grunstein, RR (2013) A new EEG biomarker of neurobehavioural impairment and sleepiness in sleep apnea patients and controls during extended wakefulness. Clin Neurophysiol.

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Abstract

OBJECTIVE: To explore the use of detrended fluctuation analysis (DFA) scaling exponent of the awake electroencephalogram (EEG) as a new alternative biomarker of neurobehavioural impairment and sleepiness in obstructive sleep apnea (OSA). METHODS: Eight patients with moderate-severe OSA and nine non-OSA controls underwent a 40-h extended wakefulness challenge with resting awake EEG, neurobehavioural performance (driving simulator and psychomotor vigilance task) and subjective sleepiness recorded every 2-h. The DFA scaling exponent and power spectra of the EEG were calculated at each time point and their correlation with sleepiness and performance were quantified. RESULTS: DFA scaling exponent and power spectra biomarkers significantly correlated with simultaneously tested performance and self-rated sleepiness across the testing period in OSA patients and controls. Baseline (8am) DFA scaling exponent but not power spectra were markers of impaired simulated driving after 24-h extended wakefulness in OSA (r=0.738, p=0.037). OSA patients had a higher scaling exponent and delta power during wakefulness than controls. CONCLUSIONS: The DFA scaling exponent of the awake EEG performed as well as conventional power spectra as a marker of impaired performance and sleepiness resulting from sleep loss. SIGNIFICANCE: DFA may potentially identify patients at risk of neurobehavioural impairment and assess treatment effectiveness.

Item Type: Article
Authors :
NameEmailORCID
D'Rozario, ALUNSPECIFIEDUNSPECIFIED
Kim, JWUNSPECIFIEDUNSPECIFIED
Wong, KKUNSPECIFIEDUNSPECIFIED
Bartlett, DJUNSPECIFIEDUNSPECIFIED
Marshall, NSUNSPECIFIEDUNSPECIFIED
Dijk, DJd.j.dijk@surrey.ac.ukUNSPECIFIED
Robinson, PAUNSPECIFIEDUNSPECIFIED
Grunstein, RRUNSPECIFIEDUNSPECIFIED
Date : 4 April 2013
Identification Number : 10.1016/j.clinph.2013.02.022
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:52
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825442

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