Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples.

Hall, JS, Leong, HS, Armenoult, LS, Newton, GE, Valentine, HR, Irlam, JJ, Möller-Levet, C, Sikand, KA, Pepper, SD, Miller, CJ et al and West, CM (2011) Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples. Br J Cancer, 104 (6). pp. 971-981.

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Abstract

Degradation and chemical modification of RNA in formalin-fixed paraffin-embedded (FFPE) samples hamper their use in expression profiling studies. This study aimed to show that useful information can be obtained by Exon-array profiling archival FFPE tumour samples.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Hall, JS, Leong, HS, Armenoult, LS, Newton, GE, Valentine, HR, Irlam, JJ, Möller-Levet, C, Sikand, KA, Pepper, SD, Miller, CJ and West, CM
Date :	15 March 2011
DOI :	10.1038/bjc.2011.66
Uncontrolled Keywords :	Adenocarcinoma, Biopsy, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Exons, Female, Fixatives, Formaldehyde, Gene Expression Profiling, Humans, Microarray Analysis, Neoplasms, Paraffin Embedding, Time Factors, Tissue Fixation, Tissue Preservation, Uterine Cervical Neoplasms
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 09:52
Last Modified :	24 Jan 2020 17:51
URI:	http://epubs.surrey.ac.uk/id/eprint/825424

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