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Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples.

Hall, JS, Leong, HS, Armenoult, LS, Newton, GE, Valentine, HR, Irlam, JJ, Möller-Levet, C, Sikand, KA, Pepper, SD, Miller, CJ and West, CM (2011) Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples. Br J Cancer, 104 (6). pp. 971-981.

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Abstract

Degradation and chemical modification of RNA in formalin-fixed paraffin-embedded (FFPE) samples hamper their use in expression profiling studies. This study aimed to show that useful information can be obtained by Exon-array profiling archival FFPE tumour samples.

Item Type: Article
Authors :
NameEmailORCID
Hall, JSUNSPECIFIEDUNSPECIFIED
Leong, HSUNSPECIFIEDUNSPECIFIED
Armenoult, LSUNSPECIFIEDUNSPECIFIED
Newton, GEUNSPECIFIEDUNSPECIFIED
Valentine, HRUNSPECIFIEDUNSPECIFIED
Irlam, JJUNSPECIFIEDUNSPECIFIED
Möller-Levet, CUNSPECIFIEDUNSPECIFIED
Sikand, KAUNSPECIFIEDUNSPECIFIED
Pepper, SDUNSPECIFIEDUNSPECIFIED
Miller, CJUNSPECIFIEDUNSPECIFIED
West, CMUNSPECIFIEDUNSPECIFIED
Date : 15 March 2011
Identification Number : https://doi.org/10.1038/bjc.2011.66
Uncontrolled Keywords : Adenocarcinoma, Biopsy, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Exons, Female, Fixatives, Formaldehyde, Gene Expression Profiling, Humans, Microarray Analysis, Neoplasms, Paraffin Embedding, Time Factors, Tissue Fixation, Tissue Preservation, Uterine Cervical Neoplasms
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:52
Last Modified : 17 May 2017 09:52
URI: http://epubs.surrey.ac.uk/id/eprint/825424

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