Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma.

Betts, GN, Eustace, A, Patiar, S, Valentine, HR, Irlam, J, Ramachandran, A, Merve, A, Homer, JJ, Möller-Levet, C, Buffa, FM et al, Hall, G, Miller, CJ, Harris, AL and West, CM (2013) Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma. Eur J Cancer, 49 (1). pp. 156-165.

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Abstract

Tumour hypoxia is associated with a poor prognosis in head and neck squamous cell carcinoma (HNSCC), however there is no accepted method for assessing hypoxia clinically. We aimed to conduct a technical validation of a hypoxia gene expression signature using the TaqMan Low Density Array (TLDA) platform to investigate if this approach reliably identified hypoxic tumours.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Betts, GN, Eustace, A, Patiar, S, Valentine, HR, Irlam, J, Ramachandran, A, Merve, A, Homer, JJ, Möller-Levet, C, Buffa, FM, Hall, G, Miller, CJ, Harris, AL and West, CM
Date :	January 2013
DOI :	10.1016/j.ejca.2012.07.028
Uncontrolled Keywords :	Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Cell Hypoxia, Female, Gene Expression Profiling, Head and Neck Neoplasms, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Staging, Real-Time Polymerase Chain Reaction, Reproducibility of Results, Reverse Transcriptase Polymerase Chain Reaction, Sensitivity and Specificity, Transcriptome
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 09:52
Last Modified :	24 Jan 2020 17:51
URI:	http://epubs.surrey.ac.uk/id/eprint/825423

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