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Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma.

Betts, GN, Eustace, A, Patiar, S, Valentine, HR, Irlam, J, Ramachandran, A, Merve, A, Homer, JJ, Möller-Levet, C, Buffa, FM , Hall, G, Miller, CJ, Harris, AL and West, CM (2013) Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma. Eur J Cancer, 49 (1). pp. 156-165.

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Abstract

Tumour hypoxia is associated with a poor prognosis in head and neck squamous cell carcinoma (HNSCC), however there is no accepted method for assessing hypoxia clinically. We aimed to conduct a technical validation of a hypoxia gene expression signature using the TaqMan Low Density Array (TLDA) platform to investigate if this approach reliably identified hypoxic tumours.

Item Type: Article
Authors :
NameEmailORCID
Betts, GNUNSPECIFIEDUNSPECIFIED
Eustace, AUNSPECIFIEDUNSPECIFIED
Patiar, SUNSPECIFIEDUNSPECIFIED
Valentine, HRUNSPECIFIEDUNSPECIFIED
Irlam, JUNSPECIFIEDUNSPECIFIED
Ramachandran, AUNSPECIFIEDUNSPECIFIED
Merve, AUNSPECIFIEDUNSPECIFIED
Homer, JJUNSPECIFIEDUNSPECIFIED
Möller-Levet, CUNSPECIFIEDUNSPECIFIED
Buffa, FMUNSPECIFIEDUNSPECIFIED
Hall, GUNSPECIFIEDUNSPECIFIED
Miller, CJUNSPECIFIEDUNSPECIFIED
Harris, ALUNSPECIFIEDUNSPECIFIED
West, CMUNSPECIFIEDUNSPECIFIED
Date : January 2013
Identification Number : 10.1016/j.ejca.2012.07.028
Uncontrolled Keywords : Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Cell Hypoxia, Female, Gene Expression Profiling, Head and Neck Neoplasms, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Staging, Real-Time Polymerase Chain Reaction, Reproducibility of Results, Reverse Transcriptase Polymerase Chain Reaction, Sensitivity and Specificity, Transcriptome
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:52
Last Modified : 17 May 2017 09:52
URI: http://epubs.surrey.ac.uk/id/eprint/825423

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