Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3.
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Mutocheluh, M, Hindle, L, Aresté, C, Chanas, SA, Butler, LM, Lowry, K, Shah, K, Evans, DJ and Blackbourn, DJ (2011) Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3. J Gen Virol, 92 (Pt 10). pp. 2394-2398.
Full text not available from this repository.Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition of interferon-response element signalling following type I interferon (IFN) induction. Western blot and electrophoretic mobility-shift assays identified the interferon-stimulated gene factor-3 (ISGF-3) components STAT1 and IRF-9 as the proximal targets of vIRF-2 activity. The biological significance of vIRF-2 inhibition of ISGF-3 was demonstrated by vIRF-2-mediated rescue of the replication of the IFN-sensitive virus encephalomyocarditis virus. This study provides both a mechanism and evidence for KSHV vIRF-2-mediated suppression of the consequences of type 1 IFN-induced signalling.
| Item Type: | Article | ||||||||||||||||||||||||||||||
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| Date : | October 2011 | ||||||||||||||||||||||||||||||
| DOI : | 10.1099/vir.0.034322-0 | ||||||||||||||||||||||||||||||
| Uncontrolled Keywords : | Blotting, Western, Electrophoretic Mobility Shift Assay, Encephalomyocarditis virus, Herpesvirus 8, Human, Immune Evasion, Interferon Regulatory Factors, Interferon Type I, Interferon-Stimulated Gene Factor 3, gamma Subunit, STAT1 Transcription Factor, Viral Proteins, Virus Replication | ||||||||||||||||||||||||||||||
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| Depositing User : | Symplectic Elements | ||||||||||||||||||||||||||||||
| Date Deposited : | 17 May 2017 09:51 | ||||||||||||||||||||||||||||||
| Last Modified : | 16 Jan 2019 17:50 | ||||||||||||||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/825380 |
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