University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3.

Mutocheluh, M, Hindle, L, Aresté, C, Chanas, SA, Butler, LM, Lowry, K, Shah, K, Evans, DJ and Blackbourn, DJ (2011) Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3. J Gen Virol, 92 (Pt 10). pp. 2394-2398.

Full text not available from this repository.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition of interferon-response element signalling following type I interferon (IFN) induction. Western blot and electrophoretic mobility-shift assays identified the interferon-stimulated gene factor-3 (ISGF-3) components STAT1 and IRF-9 as the proximal targets of vIRF-2 activity. The biological significance of vIRF-2 inhibition of ISGF-3 was demonstrated by vIRF-2-mediated rescue of the replication of the IFN-sensitive virus encephalomyocarditis virus. This study provides both a mechanism and evidence for KSHV vIRF-2-mediated suppression of the consequences of type 1 IFN-induced signalling.

Item Type: Article
Authors :
NameEmailORCID
Mutocheluh, MUNSPECIFIEDUNSPECIFIED
Hindle, LUNSPECIFIEDUNSPECIFIED
Aresté, CUNSPECIFIEDUNSPECIFIED
Chanas, SAUNSPECIFIEDUNSPECIFIED
Butler, LMUNSPECIFIEDUNSPECIFIED
Lowry, KUNSPECIFIEDUNSPECIFIED
Shah, KUNSPECIFIEDUNSPECIFIED
Evans, DJUNSPECIFIEDUNSPECIFIED
Blackbourn, DJd.blackbourn@surrey.ac.ukUNSPECIFIED
Date : October 2011
Identification Number : 10.1099/vir.0.034322-0
Uncontrolled Keywords : Blotting, Western, Electrophoretic Mobility Shift Assay, Encephalomyocarditis virus, Herpesvirus 8, Human, Immune Evasion, Interferon Regulatory Factors, Interferon Type I, Interferon-Stimulated Gene Factor 3, gamma Subunit, STAT1 Transcription Factor, Viral Proteins, Virus Replication
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:51
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825380

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800