University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Determination Of Chlorpromazine And Its Sulfoxide And 7—Hydroxy Metabolites By Ion-Pair High Pressure Liquid Chromatography

Stevenson, D and Reid, E (1981) Determination Of Chlorpromazine And Its Sulfoxide And 7—Hydroxy Metabolites By Ion-Pair High Pressure Liquid Chromatography Analytical Letters, 14 (10). pp. 741-761.

Full text not available from this repository.

Abstract

An ion-pair HPLC approach with ordinary silica has been applied, with detection by ultraviolet absorption, to the assay of plasma for chlorpromazine and its sulfoxide on the one hand, and for 7-hydroxychlorpromazine (an active metabolite) on the other hand. The respective sample-preparation procedures entail extraction of the plasma with heptane at strongly alkaline pH, or else with diethyl ether at a less alkaline pH and with ensuing back-extraction and re-extraction. For each of the compounds, levels as low as 10 ng.ml-1 are measurable. The conditions. © 1981, Taylor & Francis Group, LLC. All rights reserved.

Item Type: Article
Authors :
NameEmailORCID
Stevenson, Dd.stevenson@surrey.ac.ukUNSPECIFIED
Reid, EUNSPECIFIEDUNSPECIFIED
Date : 1 January 1981
Identification Number : 10.1080/00032718108055479
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:51
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825369

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800