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Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway.

Twigger, K, Roulstone, V, Kyula, J, Karapanagiotou, EM, Syrigos, KN, Morgan, R, White, C, Bhide, S, Nuovo, G, Coffey, M, Thompson, B, Jebar, A, Errington, F, Melcher, AA, Vile, RG, Pandha, HS and Harrington, KJ (2012) Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway. BMC Cancer, 12.

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Abstract

Reovirus exploits aberrant signalling downstream of Ras to mediate tumor-specific oncolysis. Since ~90% squamous cell carcinomas of the head and neck (SCCHN) over-express EGFR and SCCHN cell lines are sensitive to oncolytic reovirus, we conducted a detailed analysis of the effects of reovirus in 15 head and neck cancer cell lines. Both pre- and post-entry events were studied in an attempt to define biomarkers predictive of sensitivity/resistance to reovirus. In particular, we analysed the role of EGFR/Ras signalling in determining virus-mediated cytotoxicity in SCCHN.

Item Type: Article
Authors :
NameEmailORCID
Twigger, KUNSPECIFIEDUNSPECIFIED
Roulstone, VUNSPECIFIEDUNSPECIFIED
Kyula, JUNSPECIFIEDUNSPECIFIED
Karapanagiotou, EMUNSPECIFIEDUNSPECIFIED
Syrigos, KNUNSPECIFIEDUNSPECIFIED
Morgan, Rr.morgan@surrey.ac.ukUNSPECIFIED
White, CUNSPECIFIEDUNSPECIFIED
Bhide, SUNSPECIFIEDUNSPECIFIED
Nuovo, GUNSPECIFIEDUNSPECIFIED
Coffey, MUNSPECIFIEDUNSPECIFIED
Thompson, BUNSPECIFIEDUNSPECIFIED
Jebar, AUNSPECIFIEDUNSPECIFIED
Errington, FUNSPECIFIEDUNSPECIFIED
Melcher, AAUNSPECIFIEDUNSPECIFIED
Vile, RGUNSPECIFIEDUNSPECIFIED
Pandha, HSh.pandha@surrey.ac.ukUNSPECIFIED
Harrington, KJUNSPECIFIEDUNSPECIFIED
Date : 2012
Identification Number : https://doi.org/10.1186/1471-2407-12-368
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:49
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825240

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