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NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach.

Healy, DG, Abou-Sleiman, PM, Ahmadi, KR, Gandhi, S, Muqit, MM, Bhatia, KP, Quinn, NP, Lees, AJ, Holton, JL, Revesz, T and Wood, NW (2006) NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach. Mov Disord, 21 (11). pp. 1960-1963.

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The NR4A2 gene, which may cause autosomal dominant Parkinson's disease (PD), has also been reported to be a susceptibility factor for sporadic PD. Here, we use a haplotype-tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Healy, DG
Abou-Sleiman, PM
Gandhi, S
Muqit, MM
Bhatia, KP
Quinn, NP
Lees, AJ
Holton, JL
Revesz, T
Wood, NW
Date : November 2006
DOI : 10.1002/mds.21018
Uncontrolled Keywords : Case-Control Studies, Chi-Square Distribution, DNA-Binding Proteins, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Male, Middle Aged, Nuclear Receptor Subfamily 4, Group A, Member 2, Parkinson Disease, Transcription Factors
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:48
Last Modified : 24 Jan 2020 17:42

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