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Genetic epidemiology of induced CYP3A4 activity.

Rahmioglu, N, Heaton, J, Clement, G, Gill, R, Surdulescu, G, Zlobecka, K, Hodgkiss, D, Ma, Y, Hider, RC, Smith, NW and Ahmadi, KR (2011) Genetic epidemiology of induced CYP3A4 activity. Pharmacogenet Genomics, 21 (10). pp. 642-651.

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Abstract

The cytochrome P450 3A4 (CYP3A4) enzyme is implicated in the metabolism of more than 50% of all prescribed medications and its activity - including induced or inhibited activity - is deemed to be a crucial determinant of interindividual variability in drug disposition, poor therapeutic efficacy, and adverse response to medication.

Item Type: Article
Authors :
NameEmailORCID
Rahmioglu, NUNSPECIFIEDUNSPECIFIED
Heaton, JUNSPECIFIEDUNSPECIFIED
Clement, GUNSPECIFIEDUNSPECIFIED
Gill, RUNSPECIFIEDUNSPECIFIED
Surdulescu, GUNSPECIFIEDUNSPECIFIED
Zlobecka, KUNSPECIFIEDUNSPECIFIED
Hodgkiss, DUNSPECIFIEDUNSPECIFIED
Ma, YUNSPECIFIEDUNSPECIFIED
Hider, RCUNSPECIFIEDUNSPECIFIED
Smith, NWUNSPECIFIEDUNSPECIFIED
Ahmadi, KRk.ahmadi@surrey.ac.ukUNSPECIFIED
Date : October 2011
Identification Number : 10.1097/FPC.0b013e3283498ecf
Uncontrolled Keywords : Aged, Aged, 80 and over, Alcohol Drinking, Biomarkers, Pharmacological, Body Mass Index, Cytochrome P-450 CYP3A, Female, Humans, Hypericum, Middle Aged, Models, Genetic, Plant Extracts, Questionnaires, Quinidine, Quinine, Smoking
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:48
Last Modified : 17 May 2017 14:45
URI: http://epubs.surrey.ac.uk/id/eprint/825177

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