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RNA editing by base deamination: more enzymes, more targets, new mysteries.

Gerber, AP and Keller, W (2001) RNA editing by base deamination: more enzymes, more targets, new mysteries. Trends Biochem Sci, 26 (6). pp. 376-384.

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Abstract

The posttranscriptional modification of messenger RNA precursors (pre-mRNAs) by base deamination can profoundly alter the physiological function of the encoded proteins. The recent identification of tRNA-specific adenosine deaminases (ADATs) has led to the suggestion that these enzymes, as well as the cytidine and adenosine deaminases acting on pre-mRNAs (CDARs and ADARs), belong to a superfamily of RNA-dependent deaminases. This superfamily might have evolved from an ancient cytidine deaminase. This article reviews the reactions catalysed by these enzymes and discusses their evolutionary relationships.

Item Type: Article
Authors :
NameEmailORCID
Gerber, APa.gerber@surrey.ac.ukUNSPECIFIED
Keller, WUNSPECIFIEDUNSPECIFIED
Date : June 2001
Uncontrolled Keywords : Adenosine Deaminase, Amino Acid Sequence, Base Sequence, Cytidine Deaminase, Deamination, Molecular Sequence Data, Nucleic Acid Conformation, Nucleotides, RNA, RNA Editing, Sequence Homology, Amino Acid, Substrate Specificity
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:47
Last Modified : 17 May 2017 14:44
URI: http://epubs.surrey.ac.uk/id/eprint/825160

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