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Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells.

Waheed, A, Barker, J, Barton, SJ, Khan, GM, Najm-Us-Saqib, Q, Hussain, M, Ahmed, S, Owen, C and Carew, MA (2011) Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells. J Ethnopharmacol, 137 (3). pp. 1189-1196.

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Abstract

Pregnane glycosides are potent cytotoxic agents which may represent new leads in the development of anti-tumour drugs, particularly in the treatment of breast cancer, because of the structural similarity to estrogenic agonists. Caralluma species are natural sources of a wide variety of pregnane glycosides. The aim of the study was to isolate, using an activity-guided fractionation approach, novel pregnane glycosides for testing on breast cancer and other tumour lines.

Item Type: Article
Authors :
NameEmailORCID
Waheed, Aa.waheed@surrey.ac.ukUNSPECIFIED
Barker, JUNSPECIFIEDUNSPECIFIED
Barton, SJUNSPECIFIEDUNSPECIFIED
Khan, GMUNSPECIFIEDUNSPECIFIED
Najm-Us-Saqib, QUNSPECIFIEDUNSPECIFIED
Hussain, MUNSPECIFIEDUNSPECIFIED
Ahmed, SUNSPECIFIEDUNSPECIFIED
Owen, CUNSPECIFIEDUNSPECIFIED
Carew, MAUNSPECIFIEDUNSPECIFIED
Date : 11 October 2011
Identification Number : https://doi.org/10.1016/j.jep.2011.07.049
Uncontrolled Keywords : Acylation, Amino Acid Chloromethyl Ketones, Androstanols, Antineoplastic Agents, Phytogenic, Apoptosis, Asclepiadaceae, Blotting, Western, Caco-2 Cells, Caspase Inhibitors, Caspases, Cell Proliferation, Cell Survival, Chemical Fractionation, Chromatography, Cysteine Proteinase Inhibitors, Dose-Response Relationship, Drug, Glycosides, Human Umbilical Vein Endothelial Cells, Humans, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Structure, Neoplasms, Plants, Medicinal, Poly(ADP-ribose) Polymerases, Pregnanes, Structure-Activity Relationship, U937 Cells
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:47
Last Modified : 17 May 2017 14:44
URI: http://epubs.surrey.ac.uk/id/eprint/825148

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