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DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome.

Mercer, JR, Cheng, KK, Figg, N, Gorenne, I, Mahmoudi, M, Griffin, J, Vidal-Puig, A, Logan, A, Murphy, MP and Bennett, M (2010) DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res, 107 (8). pp. 1021-1031.

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Abstract

DNA damage is present in both genomic and mitochondrial DNA in atherosclerosis. However, whether DNA damage itself promotes atherosclerosis, or is simply a byproduct of the risk factors that promote atherosclerosis, is unknown.

Item Type: Article
Authors :
NameEmailORCID
Mercer, JRUNSPECIFIEDUNSPECIFIED
Cheng, KKUNSPECIFIEDUNSPECIFIED
Figg, NUNSPECIFIEDUNSPECIFIED
Gorenne, IUNSPECIFIEDUNSPECIFIED
Mahmoudi, Mm.mahmoudi@surrey.ac.ukUNSPECIFIED
Griffin, JUNSPECIFIEDUNSPECIFIED
Vidal-Puig, AUNSPECIFIEDUNSPECIFIED
Logan, AUNSPECIFIEDUNSPECIFIED
Murphy, MPUNSPECIFIEDUNSPECIFIED
Bennett, MUNSPECIFIEDUNSPECIFIED
Date : 15 October 2010
Identification Number : 10.1161/CIRCRESAHA.110.218966
Uncontrolled Keywords : Animals, Apolipoproteins E, Atherosclerosis, Cell Cycle Proteins, DNA Damage, DNA, Mitochondrial, DNA-Binding Proteins, Dietary Fats, Haplotypes, Hyperlipidemias, Metabolic Syndrome X, Metabolomics, Mice, Mice, Mutant Strains, Mitochondria, Muscle, Smooth, Vascular, Oxidative Phosphorylation, Protein-Serine-Threonine Kinases, Tumor Suppressor Proteins
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:46
Last Modified : 17 May 2017 09:46
URI: http://epubs.surrey.ac.uk/id/eprint/825065

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