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A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin.

Rayman, MP, Blundell-Pound, G, Pastor-Barriuso, R, Guallar, E, Steinbrenner, H and Stranges, S (2012) A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin. PLoS One, 7 (9).

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Abstract

Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect of selenium supplementation on the risk of type-2 diabetes in a population of relatively low selenium status as part of the UK PRECISE (PREvention of Cancer by Intervention with SElenium) pilot study. Plasma adiponectin concentration, a recognised independent predictor of type-2 diabetes risk and known to be correlated with circulating selenoprotein P, was the biomarker chosen.

Item Type: Article
Authors :
NameEmailORCID
Rayman, MPm.rayman@surrey.ac.ukUNSPECIFIED
Blundell-Pound, GUNSPECIFIEDUNSPECIFIED
Pastor-Barriuso, RUNSPECIFIEDUNSPECIFIED
Guallar, EUNSPECIFIEDUNSPECIFIED
Steinbrenner, HUNSPECIFIEDUNSPECIFIED
Stranges, SUNSPECIFIEDUNSPECIFIED
Date : 2012
Identification Number : https://doi.org/10.1371/journal.pone.0045269
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:45
Last Modified : 17 May 2017 14:44
URI: http://epubs.surrey.ac.uk/id/eprint/825025

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