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n-3 polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice.

Vancassel, S, Leman, S, Hanonick, L, Denis, S, Roger, J, Nollet, M, Bodard, S, Kousignian, I, Belzung, C and Chalon, S (2008) n-3 polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice. J Lipid Res, 49 (2). pp. 340-348.

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Abstract

The aim of this study was to examine the effects of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on stress responses in mice subjected to an unpredictable chronic mild stress (UCMS) procedure. Stress-induced modifications in coat and aggressiveness were evaluated, and phospholipid PUFA profiles and monoamine levels were analyzed in the frontal cortex, hippocampus, and striatum. The results showed that repeated exposure to mild stressors induced degradation in the physical state of the coat, lowered body weight gain, and increased aggressiveness, without any effect of n-3 PUFA supplementation. The UCMS induced a significant decrease in the levels of norepinephrine in the frontal cortex and striatum, and a nonsignificant decrease in the hippocampus. The tissue levels of serotonin (5-HT) were 40% to 65% decreased in the three brain regions studied. Interestingly, the n-3 PUFA supplementation reversed this stress-induced reduction in 5-HT levels. These findings showed that supplementation in n-3 long-chain PUFAs might reverse certain effects of UCMS in cerebral structures involved in stress-related behaviors.

Item Type: Article
Authors :
NameEmailORCID
Vancassel, SUNSPECIFIEDUNSPECIFIED
Leman, SUNSPECIFIEDUNSPECIFIED
Hanonick, LUNSPECIFIEDUNSPECIFIED
Denis, SUNSPECIFIEDUNSPECIFIED
Roger, JUNSPECIFIEDUNSPECIFIED
Nollet, Mm.nollet@surrey.ac.ukUNSPECIFIED
Bodard, SUNSPECIFIEDUNSPECIFIED
Kousignian, IUNSPECIFIEDUNSPECIFIED
Belzung, CUNSPECIFIEDUNSPECIFIED
Chalon, SUNSPECIFIEDUNSPECIFIED
Date : February 2008
Identification Number : 10.1194/jlr.M700328-JLR200
Uncontrolled Keywords : Animals, Behavior, Animal, Biogenic Monoamines, Brain, Dietary Supplements, Fatty Acids, Omega-3, Male, Mice, Mice, Inbred BALB C, Phospholipids, Predictive Value of Tests, Reaction Time, Stress, Psychological
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:45
Last Modified : 17 May 2017 14:44
URI: http://epubs.surrey.ac.uk/id/eprint/825015

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