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Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices.

Ioannides, C (2012) Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices. Xenobiotica.

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Abstract

Induction of the drug-metabolising enzyme systems is a major cause of clinically relevant drug interactions. The potential of a drug to engage in such interactions may be assessed in in vitro systems such as precision-cut tissue slices. Precision-cut tissue slices have a number of important advantages compared with the use of cells in culture, especially when tissues with a heterogeneous cellular population are concerned. Extensive studies concerned with the induction of cytochrome P450 and Phase II enzymes in precision-cut tissue slices from various animal and human tissues, such as liver, lung and intestine, using established inducing agents have revealed that slices mimic the in vivo situation. Precision-cut tissue slices is a reliable, informative and cost-effective technique for assessing the potential of chemicals to up-regulate drug-metabolising enzyme systems.

Item Type: Article
Authors :
NameEmailORCID
Ioannides, Cc.ioannides@surrey.ac.ukUNSPECIFIED
Date : 28 June 2012
Identification Number : https://doi.org/10.3109/00498254.2012.698766
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:44
Last Modified : 17 May 2017 14:44
URI: http://epubs.surrey.ac.uk/id/eprint/824932

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