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Human responses to bright light of different durations.

Chang, AM, Santhi, N, St Hilaire, M, Gronfier, C, Bradstreet, DS, Duffy, JF, Lockley, SW, Kronauer, RE and Czeisler, CA (2012) Human responses to bright light of different durations. J Physiol, 590 (Pt 13). pp. 3103-3112.

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Abstract

Light exposure in the early night induces phase delays of the circadian rhythm in melatonin in humans. Previous studies have investigated the effect of timing, intensity, wavelength, history and pattern of light stimuli on the human circadian timing system. We present results from a study of the duration–response relationship to phase-delaying bright light. Thirty-nine young healthy participants (16 female; 22.18±3.62 years) completed a 9-day inpatient study. Following three baseline days, participants underwent an initial circadian phase assessment procedure in dim light (<3 lux), and were then randomized for exposure to a bright light pulse (∼10,000 lux) of 0.2 h, 1.0 h, 2.5 h or 4.0 h duration during a 4.5 h controlled-posture episode centred in a 16 h wake episode. After another 8 h sleep episode, participants completed a second circadian phase assessment. Phase shifts were calculated from the difference in the clock time of the dim light melatonin onset (DLMO) between the initial and final phase assessments. Exposure to varying durations of bright light reset the circadian pacemaker in a dose-dependent, non-linear manner. Per minute of exposure, the 0.2 h duration was over 5 times more effective at phase delaying the circadian pacemaker (1.07±0.36 h) as compared with the 4.0 h duration (2.65±0.24 h). Acute melatonin suppression and subjective sleepiness also had a dose-dependent response to light exposure duration. These results provide strong evidence for a non-linear resetting response of the human circadian pacemaker to light duration.

Item Type: Article
Authors :
NameEmailORCID
Chang, AMUNSPECIFIEDUNSPECIFIED
Santhi, Nn.santhi@surrey.ac.ukUNSPECIFIED
St Hilaire, MUNSPECIFIEDUNSPECIFIED
Gronfier, CUNSPECIFIEDUNSPECIFIED
Bradstreet, DSUNSPECIFIEDUNSPECIFIED
Duffy, JFUNSPECIFIEDUNSPECIFIED
Lockley, SWUNSPECIFIEDUNSPECIFIED
Kronauer, REUNSPECIFIEDUNSPECIFIED
Czeisler, CAUNSPECIFIEDUNSPECIFIED
Date : 1 July 2012
Identification Number : https://doi.org/10.1113/jphysiol.2011.226555
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:43
Last Modified : 17 May 2017 14:44
URI: http://epubs.surrey.ac.uk/id/eprint/824837

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