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Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial.

Heller, S, Buse, J, Fisher, M, Garg, S, Marre, M, Merker, L, Renard, E, Russell-Jones, D, Philotheou, A, Francisco, AM , Pei, H, Bode, B and BEGIN Basal-Bolus Type 1 Trial Investigators, (2012) Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet, 379 (9825). pp. 1489-1497.

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Abstract

Intensive basal-bolus insulin therapy has been shown to improve glycaemic control and reduce the risk of long-term complications that are associated with type 1 diabetes mellitus. Insulin degludec is a new, ultra-longacting basal insulin. We therefore compared the efficacy and safety of insulin degludec and insulin glargine, both administered once daily with mealtime insulin aspart, in basal-bolus therapy for type 1 diabetes.

Item Type: Article
Authors :
NameEmailORCID
Heller, SUNSPECIFIEDUNSPECIFIED
Buse, JUNSPECIFIEDUNSPECIFIED
Fisher, MUNSPECIFIEDUNSPECIFIED
Garg, SUNSPECIFIEDUNSPECIFIED
Marre, MUNSPECIFIEDUNSPECIFIED
Merker, LUNSPECIFIEDUNSPECIFIED
Renard, EUNSPECIFIEDUNSPECIFIED
Russell-Jones, Ddavidrussell-jones@nhs.netUNSPECIFIED
Philotheou, AUNSPECIFIEDUNSPECIFIED
Francisco, AMUNSPECIFIEDUNSPECIFIED
Pei, HUNSPECIFIEDUNSPECIFIED
Bode, BUNSPECIFIEDUNSPECIFIED
BEGIN Basal-Bolus Type 1 Trial Investigators, UNSPECIFIEDUNSPECIFIED
Date : 21 April 2012
Identification Number : 10.1016/S0140-6736(12)60204-9
Uncontrolled Keywords : Adult, Diabetes Mellitus, Type 1, Drug Administration Schedule, Female, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin Aspart, Insulin, Long-Acting, Male
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:43
Last Modified : 17 May 2017 09:43
URI: http://epubs.surrey.ac.uk/id/eprint/824830

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