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Reduction of EEG theta power and changes in motor activity in rats treated with ceftriaxone

Bellesi, M, Conti, F, Vyazovskiy, VV, Tononi, G, Cirelli, C and Conti, F (2012) Reduction of EEG theta power and changes in motor activity in rats treated with ceftriaxone PLoS ONE, 7 (3).

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Abstract

The glutamate transporter GLT-1 is responsible for the largest proportion of total glutamate transport. Recently, it has been demonstrated that ceftriaxone (CEF) robustly increases GLT-1 expression. In addition, physiological studies have shown that GLT-1 up-regulation strongly affects synaptic plasticity, and leads to an impairment of the prepulse inhibition, a simple form of information processing, thus suggesting that GLT-1 over-expression may lead to dysfunctions of large populations of neurons. To test this possibility, we assessed whether CEF affects cortical electrical activity by using chronic electroencephalographic (EEG) recordings in male WKY rats. Spectral analysis showed that 8 days of CEF treatment resulted in a delayed reduction in EEG theta power (7-9 Hz) in both frontal and parietal derivations. This decrease peaked at day 10, i.e., 2 days after the end of treatment, and disappeared by day 16. In addition, we found that the same CEF treatment increased motor activity, especially when EEG changes are more prominent. Taken together, these data indicate that GLT-1 up-regulation, by modulating glutamatergic transmission, impairs the activity of widespread neural circuits. In addition, the increased motor activity and prepulse inhibition alterations previously described suggest that neural circuits involved in sensorimotor control are particularly sensitive to GLT-1 up-regulation. © 2012 Bellesi et al.

Item Type: Article
Authors :
NameEmailORCID
Bellesi, MUNSPECIFIEDUNSPECIFIED
Conti, FUNSPECIFIEDUNSPECIFIED
Vyazovskiy, VVv.vyazovskiy@surrey.ac.ukUNSPECIFIED
Tononi, GUNSPECIFIEDUNSPECIFIED
Cirelli, CUNSPECIFIEDUNSPECIFIED
Conti, FUNSPECIFIEDUNSPECIFIED
Date : 30 March 2012
Identification Number : https://doi.org/10.1371/journal.pone.0034139
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:43
Last Modified : 17 May 2017 09:43
URI: http://epubs.surrey.ac.uk/id/eprint/824816

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