University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Xenobiotic-metabolizing enzyme systems and aging.

Barnett, CR and Ioannides, C (2000) Xenobiotic-metabolizing enzyme systems and aging. Methods Mol Med, 38. pp. 119-130.

Full text not available from this repository.


The human body is continuously exposed to a wide array of structurally diverse chemicals. Such exposure occurs even at the fetal stage as almost all chemicals that are present in the mother's blood can readily cross the placenta and reach the fetus. Some of these chemicals are ingested voluntarily, for example, medicines and food additives, but the vast majority are taken involuntarily, as environmental contaminants present in the air or in the occupational environment. Undoubtedly, the most important source of such chemicals is the diet, and many dietary constituents have been shown to induce many forms of toxicity including cancer (1). Exposure to chemicals is thus inevitable and unavoidable. The body cannot exploit these chemicals either to generate energy or transform them to building blocks and consequently its response is to rid itself of their presence. This chapter discusses the role of drug-metabolizing enzyme systems in this process and the effects of age. The measurement of drug-metabolizing activities is of increasing importance in the safety evaluation of drugs in humans. This chapter describes the use of alkylphenoxazone derivatives for investigating selected activities of drug-metabolizing enzymes.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Barnett, CR
Date : 2000
DOI : 10.1385/1-59259-070-5:119
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:42
Last Modified : 24 Jan 2020 17:28

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800