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Rapid and frequent induction of protective immunity exceeding UK recommendations for healthcare settings by MF59-adjuvated hepatitis B vaccine.

Lewis, DJ, Eiden, JE, Goilav, C, Langenberg, AG, Suggett, F and Griffin, GE (2003) Rapid and frequent induction of protective immunity exceeding UK recommendations for healthcare settings by MF59-adjuvated hepatitis B vaccine. Commun Dis Public Health, 6 (4). pp. 320-324.

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Abstract

The ability of three doses of a novel MF59-adjuvanted hepatitis B virus (HBV) vaccine containing surface and pre-S2 antigens given at 0, 1, and 6 months to induce levels of HBV surface antibody (sAb) > or = 100 mIU/ml was compared with a UK licensed alum-adjuvanted yeast-derived HBV vaccine in HBV-naive healthcare workers (HCWs). One month after second immunization with HBV/MF59, 100% of HCWs had sAb > or = 100 mIU/mL, compared with only 11% and 85% after two or three immunisations with Engerix-B. The sAb GMT of the Engerix B immunised group remained below 100 mIU/mL until month seven, (compared with month one for HBV/MF59), and was 123-fold lower at this time (208,561 vs. 1,686 mIU/mL). In our subjects HBV/MF59 vaccine rapidly induced sAb to levels far in excess of those recommended by the Department of Health for high-risk situations (e.g. HCWs and patients on dialysis). It has the potential for shorter schedules and reduced need for serology and boosters.

Item Type: Article
Authors :
NameEmailORCID
Lewis, DJd.j.lewis@surrey.ac.ukUNSPECIFIED
Eiden, JEUNSPECIFIEDUNSPECIFIED
Goilav, CUNSPECIFIEDUNSPECIFIED
Langenberg, AGUNSPECIFIEDUNSPECIFIED
Suggett, FUNSPECIFIEDUNSPECIFIED
Griffin, GEUNSPECIFIEDUNSPECIFIED
Date : December 2003
Uncontrolled Keywords : Adjuvants, Immunologic, Adolescent, Adult, Female, Great Britain, Hepatitis B Antibodies, Hepatitis B Vaccines, Humans, Male, Middle Aged, Polysorbates, Practice Guidelines as Topic, Squalene
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:41
Last Modified : 17 May 2017 14:44
URI: http://epubs.surrey.ac.uk/id/eprint/824713

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