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Efficacy, safety and practicability of valproate delayed release minitablets in bipolar affective disorders

Grunze, H, Amann, B, Schafer, M, Sterr, A, Schaerer, L, Wild, E and Walden, J (2000) Efficacy, safety and practicability of valproate delayed release minitablets in bipolar affective disorders Fortschritte der Neurologie Psychiatrie, 68 (11). pp. 496-502.

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Abstract

Valproate has recently emerged as a drug of first choice in treating acute mania because of its efficacy and relative safety. It can be administered as an intravenous, oral non-sustained release or oral sustained release loading therapy. A new sustained release formulation of valproate consists of 'mini-tablets' with the possible advantage of a less problematic and more reliable administration of the drug. We report on eleven patients with an acute manic exacerbation who were investigated for sufficient control of manic symptoms and the duration of building up and maintaining sufficient blood levels of valproate in once/d versus twice/d administration of valproate delayed release minitablets (VPA mrt.). Acute and prophylactic effectiveness in mania were rated with the Young-Mania Rating Scale (YMRS), respectively the Global Clinical Impression Scale for Bipolar Disorder (CGI-BP). Results: Within a short period of time sufficient blood levels in both groups (once/d versus twice/d administration) were built up. Seven of eleven patients were responders according to a reduction of 50% of the YMRS. In respect of prophylactic treatment all of the ten patients showed satisfactory results and no re-exacerbation of manic symptoms or depression.

Item Type: Article
Authors :
NameEmailORCID
Grunze, HUNSPECIFIEDUNSPECIFIED
Amann, BUNSPECIFIEDUNSPECIFIED
Schafer, MUNSPECIFIEDUNSPECIFIED
Sterr, Aa.sterr@surrey.ac.ukUNSPECIFIED
Schaerer, LUNSPECIFIEDUNSPECIFIED
Wild, EUNSPECIFIEDUNSPECIFIED
Walden, JUNSPECIFIEDUNSPECIFIED
Date : 1 January 2000
Identification Number : https://doi.org/10.1055/s-2000-10034
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:39
Last Modified : 17 May 2017 14:43
URI: http://epubs.surrey.ac.uk/id/eprint/824568

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