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Evaluation of EN2 as a urine-based biomarker for prostate cancer.

Michael, A, Plowright, L, Boxall, A, Bhatt, A, Di Palma, S, Parker, C and Pandha, H Evaluation of EN2 as a urine-based biomarker for prostate cancer. In: ASCO, 2010-06-03 - 2010-06-07, Chicago USA.

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Abstract

Background: Prostate cancer is a leading cause of cancer related death in men but its diagnosis is still complicated by the lack of a highly predictive biochemical marker. Here we show that the transcription factor Engrailed-2 is secreted from prostate tumours in a highly specific manner and is present in the urine of men with prostate cancer. Methods: Urine was collected under standardised conditions from men with prostate cancer, or with non-cancerous conditions of the prostate such as benign prostatic hypertrophy, or men who were found to have no prostate abnormalities after saturation biopsy. Results: Engrailed-2 protein was detected in the untreated, unconcentrated urine of 62% of men with prostate cancer, but only 3% of men with no prostatic abnormalities (n=258, p<0.001). Conclusions: Thus Engrailed-2 is a potential diagnostic marker for prostate cancer.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Authors :
NameEmailORCID
Michael, Aa.michael@surrey.ac.ukUNSPECIFIED
Plowright, LUNSPECIFIEDUNSPECIFIED
Boxall, Aa.boxall@surrey.ac.ukUNSPECIFIED
Bhatt, AUNSPECIFIEDUNSPECIFIED
Di Palma, SUNSPECIFIEDUNSPECIFIED
Parker, CUNSPECIFIEDUNSPECIFIED
Pandha, Hh.pandha@surrey.ac.ukUNSPECIFIED
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:38
Last Modified : 17 May 2017 14:43
URI: http://epubs.surrey.ac.uk/id/eprint/824544

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