University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Synaptic release rather than failure in the conditioning pulse results in paired-pulse facilitation during minimal synaptic stimulation in the rat hippocampal CA1 neurones.

Chen, Y, Chad, JE and Wheal, HV (1996) Synaptic release rather than failure in the conditioning pulse results in paired-pulse facilitation during minimal synaptic stimulation in the rat hippocampal CA1 neurones. Neurosci Lett, 218 (3). pp. 204-208.

Full text not available from this repository.

Abstract

In this paper we report our observations of the relationship of paired-pulse facilitation (PPF) with synaptic release or release failure at small numbers of synaptic sites. Minimal stimulation protocols were employed to enable the activation of only one or a few axons which synapse onto CA1 pyramidal cells in the hippocampus. Excitatory postsynaptic currents (EPSCs) in response to paired stimulation were measured. On the analysis of the data, we examined the effects of failure and synaptic release on PPF, and found that PPF was observed as a decrease in failures of synaptic release in response to test stimuli which were preceded by conditioning stimuli that evoked synaptic release. The test-pulse failure rate following conditioning pulse failures was indistinguishable from the overall conditioning pulse failure rate. It is postulated that the mechanism of paired-pulse facilitation is presynaptic and associated with successful synaptic release in response to the conditioning stimulus.

Item Type: Article
Authors :
NameEmailORCID
Chen, Yying.chen@surrey.ac.ukUNSPECIFIED
Chad, JEUNSPECIFIEDUNSPECIFIED
Wheal, HVUNSPECIFIEDUNSPECIFIED
Date : 8 November 1996
Uncontrolled Keywords : Animals, Electric Stimulation, Hippocampus, Male, Neuronal Plasticity, Neurons, Patch-Clamp Techniques, Rats, Rats, Wistar, Synaptic Transmission
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:35
Last Modified : 17 May 2017 14:43
URI: http://epubs.surrey.ac.uk/id/eprint/824337

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800