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Effect of growth hormone treatment on postprandial protein metabolism in growth hormone-deficient adults.

Russell-Jones, DL, Bowes, SB, Rees, SE, Jackson, NC, Weissberger, AJ, Hovorka, R, Sonksen, PH and Umpleby, AM (1998) Effect of growth hormone treatment on postprandial protein metabolism in growth hormone-deficient adults. Am J Physiol, 274 (6 Pt 1). E1050-E1056.

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Abstract

Growth hormone (GH) treatment of GH-deficient adults increases lean body mass. To investigate this anabolic effect of GH, body composition and postabsorptive and postprandial protein metabolism were measured in 12 GH-deficient adults randomized to placebo or GH treatment. Protein metabolism was measured after an infusion of [1-13C]leucine before and after a standard meal at 0 and 2 mo. After 2 mo, there was an increase in lean body mass in the GH group (P < 0. 05) but no change in the placebo group. In the postabsorptive state, there was increased nonoxidative leucine disappearance (NOLD; a measure of protein synthesis) and leucine metabolic clearance rate and decreased leucine oxidation in the GH group (P < 0.05) but no change in the placebo group. After the meal, there was an increase in NOLD and oxidation in all studies (P < 0.05), but the increase in NOLD, measured as area under the curve, was greater in the GH group (P < 0.05). This study clearly demonstrates for the first time that the increase in protein synthesis in the postabsorptive state after GH treatment of GH-deficient adults is maintained in the postprandial state.

Item Type: Article
Authors :
NameEmailORCID
Russell-Jones, DLUNSPECIFIEDUNSPECIFIED
Bowes, SBUNSPECIFIEDUNSPECIFIED
Rees, SEUNSPECIFIEDUNSPECIFIED
Jackson, NCn.jackson@surrey.ac.ukUNSPECIFIED
Weissberger, AJUNSPECIFIEDUNSPECIFIED
Hovorka, RUNSPECIFIEDUNSPECIFIED
Sonksen, PHUNSPECIFIEDUNSPECIFIED
Umpleby, AMUNSPECIFIEDUNSPECIFIED
Date : June 1998
Uncontrolled Keywords : Adult, Body Composition, C-Peptide, Carbon Isotopes, Fatty Acids, Nonesterified, Female, Food, Human Growth Hormone, Humans, Insulin-Like Growth Factor I, Leucine, Male, Metabolic Clearance Rate, Middle Aged, Placebos, Protein Biosynthesis
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:32
Last Modified : 17 May 2017 14:43
URI: http://epubs.surrey.ac.uk/id/eprint/824117

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