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The effect of recombinant human growth hormone on glucose and leucine metabolism in Cushing's syndrome.

Bowes, SB, Umpleby, M, Cummings, MH, Jackson, NC, Carroll, PV, Lowy, C, Sönksen, PH and Russell-Jones, DL (1997) The effect of recombinant human growth hormone on glucose and leucine metabolism in Cushing's syndrome. J Clin Endocrinol Metab, 82 (1). pp. 243-246.

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Abstract

Cushing's syndrome is characterized by central obesity and muscle wasting. As GH is anabolic, it may be able to counteract the loss of body protein. To evaluate the potential therapeutic use of GH preoperatively, eight patients with Cushing's syndrome received sc injections of recombinant human GH (0.07 U/kg.day) for 7 days. Whole body leucine and glucose turnover were measured after an infusion of [1-13C]leucine and [6,6-2H2]glucose before (day 0) and after 2 and 7 days of GH treatment. Compared with the value on day 0, there was a significant increase on days 2 and 7 in insulin (P < 0.005 and P < 0.001), C peptide (P < 0.01 and P < 0.005), insulin-like growth factor I (P < 0.001), and glucose concentrations (P < 0.01 and P < 0.005) and a decrease in the leucine concentration (P < 0.005). There was no significant change in glucose production rate, glucose MCR, leucine production rate (a measure of protein degradation), or nonoxidative leucine disappearance rate (a measure of protein synthesis). The leucine MCR was increased after 7 days (P < 0.05), and the clearance of leucine into protein (nonoxidative leucine disappearance rate/leucine concentration) was increased (P < 0.05) after 2 and 7 days of GH treatment. This is consistent with GH stimulating the availability of amino acid transporters. GH may, therefore, have a therapeutic role in the preoperative treatment of Cushing's syndrome.

Item Type: Article
Authors :
NameEmailORCID
Bowes, SBUNSPECIFIEDUNSPECIFIED
Umpleby, MUNSPECIFIEDUNSPECIFIED
Cummings, MHUNSPECIFIEDUNSPECIFIED
Jackson, NCn.jackson@surrey.ac.ukUNSPECIFIED
Carroll, PVUNSPECIFIEDUNSPECIFIED
Lowy, CUNSPECIFIEDUNSPECIFIED
Sönksen, PHUNSPECIFIEDUNSPECIFIED
Russell-Jones, DLUNSPECIFIEDUNSPECIFIED
Date : January 1997
Identification Number : 10.1210/jcem.82.1.3690
Uncontrolled Keywords : Adult, Blood Glucose, C-Peptide, Cushing Syndrome, Female, Human Growth Hormone, Humans, Insulin, Insulin-Like Growth Factor I, Leucine, Male, Metabolic Clearance Rate, Middle Aged, Recombinant Proteins, Reference Values
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:32
Last Modified : 17 May 2017 14:43
URI: http://epubs.surrey.ac.uk/id/eprint/824115

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