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A comparison of the effects of IGF-I and insulin on glucose metabolism, fat metabolism and the cardiovascular system in normal human volunteers.

Russell-Jones, DL, Bates, AT, Umpleby, AM, Hennessy, TR, Bowes, SB, Hopkins, KD, Jackson, N, Kelly, J, Shojaee-Moradie, F and Jones, RH (1995) A comparison of the effects of IGF-I and insulin on glucose metabolism, fat metabolism and the cardiovascular system in normal human volunteers. Eur J Clin Invest, 25 (6). pp. 403-411.

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Abstract

The metabolic and cardiovascular effects of recombinant human IGF-I were compared to insulin in six normal subjects. Subjects were studied twice and intravenously received an infusion of [6,6-2H2]glucose (0-480 min) and in random order either IGF-I 20 micrograms kg-1 h-1 (43.7 pmol kg-1 min-1 or insulin 0.5 mU kg-1 min-1 (3.4 pmol kg-1 min-1) with an euglycaemic clamp. One subject was withdrawn following a serious adverse event. During the IGF-I infusion glucose appearance rate (Ra) decreased from 1.79 +/- 0.13 at baseline (150-180 min) to 0.35 +/- 0.26 mg kg-1 min-1 (P < 0.01) at 360 min, and glucose utilization rate (Rd) increased from 1.79 +/- 0.28 to 4.17 +/- 0.84 mg kg-1 min-1 (P < 0.01). There was no change in free fatty acids (FFA) and an increase (percentage change from pre-infusion mean) in cardiac output +l37.3% +/- 9% (P < 0.01), heart rate +13% +/- 2% (P < 0.01) and stroke volume +21% +/- 7% (P < 0.05). During the insulin infusion glucose Ra decreased from 1.89 +/- 0.13 to 0.34 +/- 0.33 mg kg-1 min-1 (P < 0.01) and FFA from 0.546 mmol l-1 to 0.198 mmol l-1 (P < 0.01), glucose Rd increased from 1.89 +/- 0.18 to 5.41 +/- 1.47 mg kg-1 min-1 (P < 0.01) and there were no significant changes in the cardiovascular variables.

Item Type: Article
Authors :
NameEmailORCID
Russell-Jones, DLUNSPECIFIEDUNSPECIFIED
Bates, ATUNSPECIFIEDUNSPECIFIED
Umpleby, AMUNSPECIFIEDUNSPECIFIED
Hennessy, TRUNSPECIFIEDUNSPECIFIED
Bowes, SBUNSPECIFIEDUNSPECIFIED
Hopkins, KDUNSPECIFIEDUNSPECIFIED
Jackson, Nn.jackson@surrey.ac.ukUNSPECIFIED
Kelly, JUNSPECIFIEDUNSPECIFIED
Shojaee-Moradie, Ff.shojaee-moradie@surrey.ac.ukUNSPECIFIED
Jones, RHUNSPECIFIEDUNSPECIFIED
Date : June 1995
Uncontrolled Keywords : Adult, Fats, Fatty Acids, Nonesterified, Glucose, Hemodynamics, Humans, Insulin, Insulin-Like Growth Factor I, Male, Middle Aged
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:32
Last Modified : 17 May 2017 14:43
URI: http://epubs.surrey.ac.uk/id/eprint/824107

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