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Effects of glutamine supplementation, GH, and IGF-I on glutamine metabolism in critically ill patients.

Jackson, NC, Carroll, PV, Russell-Jones, DL, Sönksen, PH, Treacher, DF and Umpleby, AM (2000) Effects of glutamine supplementation, GH, and IGF-I on glutamine metabolism in critically ill patients. Am J Physiol Endocrinol Metab, 278 (2). E226-E233.

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Abstract

During critical illness glutamine deficiency may develop. Glutamine supplementation can restore plasma concentration to normal, but the effect on glutamine metabolism is unknown. The use of growth hormone (GH) and insulin-like growth factor I (IGF-I) to prevent protein catabolism in these patients may exacerbate the glutamine deficiency. We have investigated, in critically ill patients, the effects of 72 h of treatment with standard parenteral nutrition (TPN; n = 6), TPN supplemented with glutamine (TPNGLN; 0.4 g x kg(-1) x day(-1), n = 6), or TPNGLN with combined GH (0.2 IU. kg(-1). day(-1)) and IGF-I (160 microg x kg (-1) x day(-1)) (TPNGLN+GH/IGF-I; n = 5) on glutamine metabolism using [2-(15)N]glutamine. In patients receiving TPNGLN and TPNGLN+GH/IGF-I, plasma glutamine concentration was increased (338 +/- 22 vs. 461 +/- 24 micromol/l, P < 0.001, and 307 +/- 65 vs. 524 +/- 71 micromol/l, P < 0.05, respectively) and glutamine uptake was increased (5.2 +/- 0.5 vs. 7.4 +/- 0.7 micromol x kg(-1) x min(-1), P < 0.05 and 5.2 +/- 1.1 vs. 7.6 +/- 0.8 micromol x kg(-1) x min(-1), P < 0.05). Glutamine production and metabolic clearance rates were not altered by the three treatments. These results suggest that there is an increased requirement for glutamine in critically ill patients. Combined GH/IGF-I treatment with TPNGLN did not have adverse effects on glutamine metabolism.

Item Type: Article
Authors :
NameEmailORCID
Jackson, NCn.jackson@surrey.ac.ukUNSPECIFIED
Carroll, PVUNSPECIFIEDUNSPECIFIED
Russell-Jones, DLUNSPECIFIEDUNSPECIFIED
Sönksen, PHUNSPECIFIEDUNSPECIFIED
Treacher, DFUNSPECIFIEDUNSPECIFIED
Umpleby, AMUNSPECIFIEDUNSPECIFIED
Date : February 2000
Uncontrolled Keywords : Adult, Aged, Critical Illness, Female, Glutamine, Human Growth Hormone, Humans, Insulin-Like Growth Factor I, Male, Metabolic Clearance Rate, Middle Aged, Nutritional Requirements, Parenteral Nutrition, Total
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:32
Last Modified : 17 May 2017 14:43
URI: http://epubs.surrey.ac.uk/id/eprint/824102

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