HOX genes in pancreatic development and cancer.

Gray, S, Pandha, HS, Michael, A, Middleton, G and Morgan, R (2011) HOX genes in pancreatic development and cancer. JOP, 12 (3). pp. 216-219.

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Abstract

The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development and which are subsequently re-expressed in many types of cancer. Some recent studies have shown that HOX genes may have key roles both in pancreatic development and in adult diseases of the pancreas, including cancer. In this review we consider recent advances in elucidating the role of HOX genes in these processes, how they may connect early developmental events to subsequent adult disease, and their potential both as diagnostic markers and therapeutic targets.

Item Type:	Article
Authors :	Name Email ORCID Gray, S UNSPECIFIED UNSPECIFIED Pandha, HS h.pandha@surrey.ac.uk UNSPECIFIED Michael, A a.michael@surrey.ac.uk UNSPECIFIED Middleton, G UNSPECIFIED UNSPECIFIED Morgan, R r.morgan@surrey.ac.uk UNSPECIFIED
Date :	2011
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 09:31
Last Modified :	17 May 2017 14:43
URI:	http://epubs.surrey.ac.uk/id/eprint/824043

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