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Quantification of Behavior Sackler Colloquium: Sex difference in the near-24-hour intrinsic period of the human circadian timing system.

Duffy, JF, Cain, SW, Chang, AM, Phillips, AJ, Münch, MY, Gronfier, C, Wyatt, JK, Dijk, DJ, Wright, KP and Czeisler, CA (2011) Quantification of Behavior Sackler Colloquium: Sex difference in the near-24-hour intrinsic period of the human circadian timing system. Proc Natl Acad Sci U S A.

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Abstract

The circadian rhythms of melatonin and body temperature are set to an earlier hour in women than in men, even when the women and men maintain nearly identical and consistent bedtimes and wake times. Moreover, women tend to wake up earlier than men and exhibit a greater preference for morning activities than men. Although the neurobiological mechanism underlying this sex difference in circadian alignment is unknown, multiple studies in nonhuman animals have demonstrated a sex difference in circadian period that could account for such a difference in circadian alignment between women and men. Whether a sex difference in intrinsic circadian period in humans underlies the difference in circadian alignment between men and women is unknown. We analyzed precise estimates of intrinsic circadian period collected from 157 individuals (52 women, 105 men; aged 18-74 y) studied in a month-long inpatient protocol designed to minimize confounding influences on circadian period estimation. Overall, the average intrinsic period of the melatonin and temperature rhythms in this population was very close to 24 h [24.15 ± 0.2 h (24 h 9 min ± 12 min)]. We further found that the intrinsic circadian period was significantly shorter in women [24.09 ± 0.2 h (24 h 5 min ± 12 min)] than in men [24.19 ± 0.2 h (24 h 11 min ± 12 min); P < 0.01] and that a significantly greater proportion of women have intrinsic circadian periods shorter than 24.0 h (35% vs. 14%; P < 0.01). The shorter average intrinsic circadian period observed in women may have implications for understanding sex differences in habitual sleep duration and insomnia prevalence.

Item Type: Article
Authors :
NameEmailORCID
Duffy, JFUNSPECIFIEDUNSPECIFIED
Cain, SWUNSPECIFIEDUNSPECIFIED
Chang, AMUNSPECIFIEDUNSPECIFIED
Phillips, AJUNSPECIFIEDUNSPECIFIED
Münch, MYUNSPECIFIEDUNSPECIFIED
Gronfier, CUNSPECIFIEDUNSPECIFIED
Wyatt, JKUNSPECIFIEDUNSPECIFIED
Dijk, DJd.j.dijk@surrey.ac.ukUNSPECIFIED
Wright, KPUNSPECIFIEDUNSPECIFIED
Czeisler, CAUNSPECIFIEDUNSPECIFIED
Date : 2 May 2011
Identification Number : https://doi.org/10.1073/pnas.1010666108
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:31
Last Modified : 17 May 2017 14:43
URI: http://epubs.surrey.ac.uk/id/eprint/824042

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