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Galleria mellonella as an infection model for Campylobacter jejuni virulence.

Senior, NJ, Bagnall, MC, Champion, OL, Reynolds, SE, La Ragione, RM, Woodward, MJ, Salguero, FJ and Titball, RW (2011) Galleria mellonella as an infection model for Campylobacter jejuni virulence. J Med Microbiol, 60 (Pt 5). pp. 661-669.

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Larvae of Galleria mellonella (Greater Wax Moth) have been shown to be susceptible to Campylobacter jejuni infection and our study characterizes this infection model. Following infection with C. jejuni human isolates, bacteria were visible in the haemocoel and gut of challenged larvae, and there was extensive damage to the gut. Bacteria were found in the extracellular and cell-associated fraction in the haemocoel, and it was shown that C. jejuni can survive in insect cells. Finally, we have used the model to screen a further 67 C. jejuni isolates belonging to different MLST types. Isolates belonging to ST257 were the most virulent in the Galleria model, whereas those belonging to ST21 were the least virulent.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Senior, NJ
Bagnall, MC
Champion, OL
Reynolds, SE
La Ragione,
Salguero, FJ
Titball, RW
Date : May 2011
DOI : 10.1099/jmm.0.026658-0
Uncontrolled Keywords : Animals, Bacterial Typing Techniques, Campylobacter Infections, Campylobacter jejuni, Cell Line, Disease Models, Animal, Hemocytes, Humans, Larva, Macrophages, Mice, Moths, Multilocus Sequence Typing, Spodoptera, Virulence
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:27
Last Modified : 24 Jan 2020 16:57

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