University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Galleria mellonella as an infection model for Campylobacter jejuni virulence.

Senior, NJ, Bagnall, MC, Champion, OL, Reynolds, SE, La Ragione, RM, Woodward, MJ, Salguero, FJ and Titball, RW (2011) Galleria mellonella as an infection model for Campylobacter jejuni virulence. J Med Microbiol, 60 (Pt 5). pp. 661-669.

Full text not available from this repository.

Abstract

Larvae of Galleria mellonella (Greater Wax Moth) have been shown to be susceptible to Campylobacter jejuni infection and our study characterizes this infection model. Following infection with C. jejuni human isolates, bacteria were visible in the haemocoel and gut of challenged larvae, and there was extensive damage to the gut. Bacteria were found in the extracellular and cell-associated fraction in the haemocoel, and it was shown that C. jejuni can survive in insect cells. Finally, we have used the model to screen a further 67 C. jejuni isolates belonging to different MLST types. Isolates belonging to ST257 were the most virulent in the Galleria model, whereas those belonging to ST21 were the least virulent.

Item Type: Article
Authors :
NameEmailORCID
Senior, NJUNSPECIFIEDUNSPECIFIED
Bagnall, MCUNSPECIFIEDUNSPECIFIED
Champion, OLUNSPECIFIEDUNSPECIFIED
Reynolds, SEUNSPECIFIEDUNSPECIFIED
La Ragione, RMr.laragione@surrey.ac.ukUNSPECIFIED
Woodward, MJm.woodward@surrey.ac.ukUNSPECIFIED
Salguero, FJUNSPECIFIEDUNSPECIFIED
Titball, RWUNSPECIFIEDUNSPECIFIED
Date : May 2011
Identification Number : 10.1099/jmm.0.026658-0
Uncontrolled Keywords : Animals, Bacterial Typing Techniques, Campylobacter Infections, Campylobacter jejuni, Cell Line, Disease Models, Animal, Hemocytes, Humans, Larva, Macrophages, Mice, Moths, Multilocus Sequence Typing, Spodoptera, Virulence
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:27
Last Modified : 17 May 2017 14:42
URI: http://epubs.surrey.ac.uk/id/eprint/823766

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800