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Ligand binding of safrole to cytochrome P-450.

Delaforge, M, Ioannides, C and Parke, DV (1980) Ligand binding of safrole to cytochrome P-450. Arch Toxicol Suppl, 4. pp. 45-48.

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Safrole, a hepatocarcinogen, is converted by the microsomal mono-oxygenase system to a reactive intermediate which interacts with cytochrome P-450 to form a ligand complex. The formation of this complex is accompanied by loss of mono-oxygenase activity. The present study describes the interaction of the safrole reactive intermediate with microsomes from phenobarbital, 3-methylcholanthrene and safrole pretreated animals.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Delaforge, M
Parke, DV
Date : 1980
Uncontrolled Keywords : Animals, Binding, Competitive, Cytochrome P-450 Enzyme System, Dioxoles, In Vitro Techniques, Ligands, Male, Methylcholanthrene, Microsomes, Liver, Protein Binding, Rats, Safrole
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:21
Last Modified : 24 Jan 2020 16:42

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