University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Ligand binding of safrole to cytochrome P-450.

Delaforge, M, Ioannides, C and Parke, DV (1980) Ligand binding of safrole to cytochrome P-450. Arch Toxicol Suppl, 4. pp. 45-48.

Full text not available from this repository.

Abstract

Safrole, a hepatocarcinogen, is converted by the microsomal mono-oxygenase system to a reactive intermediate which interacts with cytochrome P-450 to form a ligand complex. The formation of this complex is accompanied by loss of mono-oxygenase activity. The present study describes the interaction of the safrole reactive intermediate with microsomes from phenobarbital, 3-methylcholanthrene and safrole pretreated animals.

Item Type: Article
Authors :
NameEmailORCID
Delaforge, MUNSPECIFIEDUNSPECIFIED
Ioannides, Cc.ioannides@surrey.ac.ukUNSPECIFIED
Parke, DVUNSPECIFIEDUNSPECIFIED
Date : 1980
Uncontrolled Keywords : Animals, Binding, Competitive, Cytochrome P-450 Enzyme System, Dioxoles, In Vitro Techniques, Ligands, Male, Methylcholanthrene, Microsomes, Liver, Protein Binding, Rats, Safrole
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:21
Last Modified : 17 May 2017 14:41
URI: http://epubs.surrey.ac.uk/id/eprint/823390

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800