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Infection of bovine dendritic cells by rinderpest or measles viruses induces different changes in host transcription.

Nanda, SK, Baron, J, Royall, E, Robinson, L, Falciani, F and Baron, MD (2009) Infection of bovine dendritic cells by rinderpest or measles viruses induces different changes in host transcription. Virology, 395 (2). pp. 223-231.

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Abstract

The morbilliviruses are a closely related genus which are very similar in their sequences and share a common receptor, but nevertheless show significant restriction in the host species in which they cause disease. One contribution to this restriction might be the nature of the hosts' responses to infection. We have used microarrays to study the changes in the transcriptome of bovine dendritic cells after infection with wild-type (pathogenic) and vaccine (apathogenic) strains of rinderpest virus (RPV), a bovine pathogen, and a wild-type isolate of measles virus (MV), a morbillivirus that causes disease only in humans and some other primates. We found that, as previously observed in human cells, MV induces a rapid interferon response, while that induced by RPV was delayed and much reduced in magnitude. Pathogenic and apathogenic RPV also showed significant differences, with the latter inducing a slightly higher interferon response as well as significant effects on transcription of genes involved in cell cycle regulation.

Item Type: Article
Authors :
NameEmailORCID
Nanda, SKUNSPECIFIEDUNSPECIFIED
Baron, JUNSPECIFIEDUNSPECIFIED
Royall, Ee.royall@surrey.ac.ukUNSPECIFIED
Robinson, LUNSPECIFIEDUNSPECIFIED
Falciani, FUNSPECIFIEDUNSPECIFIED
Baron, MDUNSPECIFIEDUNSPECIFIED
Date : 20 December 2009
Identification Number : https://doi.org/10.1016/j.virol.2009.09.031
Uncontrolled Keywords : Animals, Cattle, Dendritic Cells, Immunity, Innate, Measles virus, Rinderpest virus, Transcription, Genetic
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:17
Last Modified : 17 May 2017 14:41
URI: http://epubs.surrey.ac.uk/id/eprint/823120

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