University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Effect of menopause on melatonin and alertness rhythms investigated in constant routine conditions.

Walters, JF, Hampton, SM, Ferns, GA and Skene, DJ (2005) Effect of menopause on melatonin and alertness rhythms investigated in constant routine conditions. Chronobiol Int, 22 (5). pp. 859-872.

Full text not available from this repository.

Abstract

Although studies have reported the effects of the menstrual cycle on melatonin rhythmicity, none has investigated the effects of menopause on the melatonin rhythm. The circadian rhythm in melatonin and its relationship to subjective alertness was investigated in pre- and postmenopausal women under constant routine conditions (controlled posture, dim lighting, calorie intake, temperature, and prolonged wakefulness). Eleven healthy pre-menopausal (42+/-4 yr) and 10 postmenopausal women (55+/-2 yr) participated in the study. Salivary melatonin samples and subjective measures of alertness and sleepiness were assessed hourly during the 22 h constant routine protocol. Postmenopausal women had a significantly earlier melatonin acrophase (1.1+/-0.5 h clock time in decimal h; mean+/-SEM, p<0.05) compared to the pre-menopausal women (2.3+/-0.3 h). There was no significant difference between melatonin onset and amplitude between the pre-menopausal and postmenopausal women. Self-rated alertness declined in both study groups as the length of sleep deprivation increased. Melatonin onset preceded the onset of self-rated sleepiness in both groups. The time interval between melatonin onset and the onset of sleepiness and alertness offset was significantly greater in the postmenopausal women compared to the pre-menopausal women. In conclusion, under controlled experimental conditions the timing of the melatonin rhythm was advanced in postmenopausal women altering its phase relationship to subjective alertness and sleepiness.

Item Type: Article
Authors :
NameEmailORCID
Walters, JFUNSPECIFIEDUNSPECIFIED
Hampton, SMs.hampton@surrey.ac.ukUNSPECIFIED
Ferns, GAUNSPECIFIEDUNSPECIFIED
Skene, DJUNSPECIFIEDUNSPECIFIED
Date : 2005
Identification Number : 10.1080/07420520500263193
Uncontrolled Keywords : Adult, Circadian Rhythm, Female, Habits, Humans, Melatonin, Menopause, Middle Aged, Postmenopause, Premenopause, Saliva, Sleep, Sleep Deprivation, Time Factors, Wakefulness
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:16
Last Modified : 17 May 2017 14:41
URI: http://epubs.surrey.ac.uk/id/eprint/823001

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800