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Menin molecular interactions: insights into normal functions and tumorigenesis.

Agarwal, SK, Kennedy, PA, Scacheri, PC, Novotny, EA, Hickman, AB, Cerrato, A, Rice, TS, Moore, JB, Rao, S, Ji, Y , Mateo, C, Libutti, SK, Oliver, B, Chandrasekharappa, SC, Burns, AL, Collins, FS, Spiegel, AM and Marx, SJ (2005) Menin molecular interactions: insights into normal functions and tumorigenesis. Horm Metab Res, 37 (6). pp. 369-374.

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Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease predisposed by heterozygous germline mutations in the MEN1 tumor suppressor gene. Biallelic loss of MEN1 resulting from small mutation and/or loss of heterozygosity occurs in a large tissue spectrum of MEN1 tumors or non-hereditary tumors. Mouse models of MEN1 underexpression or overexpression have also supported the tumor-suppressor effect of the MEN1 gene. Menin, the 610-amino-acid protein encoded by MEN1, is expressed ubiquitously and found predominantly in the nucleus. Sequence analyses do not reveal motifs of known function other than two nuclear localization sequences. Menin has been found to partner in vitro with a variety of proteins that comprise transcription factors, DNA processing factors, DNA repair proteins, and cytoskeletal proteins. The diverse functions of menin interactors suggest roles for menin in multiple biological pathways. Inactivation of menin switches its JunD partner from a downstream action of growth suppression to growth promotion. This is a plausible mechanism for menin tumorigenesis.

Item Type: Article
Authors :
NameEmailORCID
Agarwal, SKUNSPECIFIEDUNSPECIFIED
Kennedy, PAUNSPECIFIEDUNSPECIFIED
Scacheri, PCUNSPECIFIEDUNSPECIFIED
Novotny, EAUNSPECIFIEDUNSPECIFIED
Hickman, ABUNSPECIFIEDUNSPECIFIED
Cerrato, AUNSPECIFIEDUNSPECIFIED
Rice, TSUNSPECIFIEDUNSPECIFIED
Moore, JBj.b.moore@surrey.ac.ukUNSPECIFIED
Rao, SUNSPECIFIEDUNSPECIFIED
Ji, YUNSPECIFIEDUNSPECIFIED
Mateo, CUNSPECIFIEDUNSPECIFIED
Libutti, SKUNSPECIFIEDUNSPECIFIED
Oliver, BUNSPECIFIEDUNSPECIFIED
Chandrasekharappa, SCUNSPECIFIEDUNSPECIFIED
Burns, ALUNSPECIFIEDUNSPECIFIED
Collins, FSUNSPECIFIEDUNSPECIFIED
Spiegel, AMUNSPECIFIEDUNSPECIFIED
Marx, SJUNSPECIFIEDUNSPECIFIED
Date : June 2005
Identification Number : 10.1055/s-2005-870139
Uncontrolled Keywords : Animals, Cell Nucleus, Cytoskeletal Proteins, DNA, Gene Expression Regulation, Neoplastic, Humans, Multiple Endocrine Neoplasia Type 1, Protein Binding, Proto-Oncogene Proteins, Transcription Factors, Transcription, Genetic
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:15
Last Modified : 17 May 2017 14:41
URI: http://epubs.surrey.ac.uk/id/eprint/822982

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