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EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques.

Lamb, DJ, Modjtahedi, H, Plant, NJ and Ferns, GA (2004) EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques. Atherosclerosis, 176 (1). pp. 21-26.

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Abstract

The recruitment of peripheral monocytes to the sub-endothelial space, their development into macrophages and subsequent proliferation are critical events during atherosclerosis. Receptors for epidermal growth factor (EGF) have been identified on cells of the myeloid lineage, but a role for them in atherogenesis has yet to be described. We have identified functional EGF receptors (EGFR, ErbB1/HER-1) on peripheral blood monocytes and monocyte-derived macrophages. Uniquely, these receptors were found to mediate both chemotaxis in monocytes and macrophages and proliferation in macrophages. EGFR mRNA was detected in atherosclerotic plaques, but not in morphologically normal aortae and EGFR receptor staining co-localised with macrophage staining in these plaques. The identification of receptors for EGF on peripheral blood monocytes, macrophages and atherosclerotic lesions, together with their transduction of two functionally important cellular events, heightens the potential importance of members of the EGF super-family in atherogenesis and other chronic inflammatory processes.

Item Type: Article
Authors :
NameEmailORCID
Lamb, DJUNSPECIFIEDUNSPECIFIED
Modjtahedi, HUNSPECIFIEDUNSPECIFIED
Plant, NJn.plant@surrey.ac.ukUNSPECIFIED
Ferns, GAUNSPECIFIEDUNSPECIFIED
Date : September 2004
Identification Number : 10.1016/j.atherosclerosis.2004.04.012
Uncontrolled Keywords : Animals, Aorta, Arteriosclerosis, Cell Division, Chemotaxis, Leukocyte, Epidermal Growth Factor, Gene Expression, Macrophages, Mitogens, Monocytes, RNA, Messenger, Rabbits, Receptor, Epidermal Growth Factor
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:15
Last Modified : 17 May 2017 09:15
URI: http://epubs.surrey.ac.uk/id/eprint/822966

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